LTA4H, leukotriene A4 hydrolase, 4048

N. diseases: 63; N. variants: 11
Disease: Coronary Artery Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2540477
rs2540477
Entrez Id: 4048
Gene Symbol: LTA4H
LTA4H
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE In Caucasians, first-stage analysis of 254 haplotype-tagging SNPs in 15 LT pathway genes with follow-up of 19 variants in stage 2 revealed an LTA4H SNP (rs2540477) that increased risk of CAD (OR = 1.2, 95% CI 1.1-1.5; p = 0.003) and a PLA2G4A SNP (rs12746200) that decreased risk of CAD (OR = 0.7, 95% CI 0.6-0.9; p = 0.0007). 21293878 2011