|
rs1041981
|
LTA;LOC100287329
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
The T60N LTA polymorphism is associated with type 2 diabetes and other features of the metabolic syndrome among Caucasian individuals.
|
15729581 |
2005 |
|
rs1041981
|
LTA;LOC100287329
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).
|
16132956 |
2005 |
|
rs1041981
|
LTA;LOC100287329
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results.
|
20177654 |
2010 |
|
rs1041981
|
LTA;LOC100287329
|
Diffuse Large B-Cell Lymphoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphisms of LTA (rs1041981) and RIPK1 (rs2272990) may correlate with TTP in patients with DLBCL treated with R-CHOP.
|
19629486 |
2010 |
|
rs1041981
|
LTA;LOC100287329
|
Diffuse Large B-Cell Lymphoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, another SNP (TNF- α rs1041981) was associated with an increased risk of DLBCL (ORper-minor-allele=1.73, 95% CI 1.14-2.61).
|
28060727 |
2017 |
|
rs1041981
|
LTA;LOC100287329
|
Periodontitis
|
|
0.020 |
GeneticVariation |
BEFREE |
The CTTAC haploblock (formed by LTA-rs2857709, LTA-rs2844484, LTA- rs2229094, LTA-rs2229092 and LTA-rs1041981 polymorphisms) correlated with protection towards periodontitis condition, after regression analysis including age and smoking status as covariates (P-value = 0.015).
|
30284722 |
2019 |
|
rs1041981
|
LTA;LOC100287329
|
Periodontitis
|
|
0.020 |
GeneticVariation |
BEFREE |
High serum LTA concentrations in the Parogene population were associated with the periodontitis risk alleles of the LTA SNPs (rs909253 and rs1041981) of the haplotype.
|
24566624 |
2014 |
|
rs909253
|
LTA;LOC100287329
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
The present meta-analysis results suggest that the LTA rs909253 GA genotype is a possible risk factor for developing gastric cancer in the Asian population, especially those with H. pylori infection.
|
22748850 |
2012 |
|
rs909253
|
LTA;LOC100287329
|
Coronary heart disease
|
|
0.020 |
GeneticVariation |
BEFREE |
The seven SNPs (including the rs909253 and rs1041981 SNPs previously implicated in the risk of CHD) were in strong linkage disequilibrium with each other and contributed to six common haplotypes.
|
16839190 |
2006 |
|
rs909253
|
LTA;LOC100287329
|
Coronary heart disease
|
|
0.020 |
GeneticVariation |
BEFREE |
The association of IFN-γ (+874 A/T; rs2430561), TNF-α (-308 G/A; rs1800629) and TNF-β (+252 A/G; rs909253) with Coronary Heart Disease (CHD) has not been rigorously tested in Indian population.
|
23159874 |
2013 |
|
rs909253
|
LTA;LOC100287329
|
Schizophrenia
|
|
0.020 |
GeneticVariation |
BEFREE |
Results confirmed previous findings from different ethnic populations, in that the rs1800497 and rs909253 polymorphisms were both associated with risk of schizophrenia.
|
26114114 |
2015 |
|
rs909253
|
LTA;LOC100287329
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Besides, rs909253 (<i>TNFB</i>) predicted protection for the overall and disease-free survivals for gastric cancer.
|
30551681 |
2018 |
|
rs909253
|
LTA;LOC100287329
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
Besides, rs909253 (<i>TNFB</i>) predicted protection for the overall and disease-free survivals for gastric cancer.
|
30551681 |
2018 |
|
rs909253
|
LTA;LOC100287329
|
Schizophrenia
|
|
0.020 |
GeneticVariation |
BEFREE |
Since growing evidences suggest the crucial and complex role of the tumor necrosis factor in the CNS, we have hypothesized that functional genetic variants of the LTA and TNFA genes (LTA +252A/G (rs909253) and TNFA -857C/T (rs1799724) and TNFA -238G/A (rs361525)) may be involved in the predisposition to schizophrenia.
|
30627222 |
2018 |
|
rs909253
|
LTA;LOC100287329
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to perform a meta-analysis of eligible studies to derive precise estimation of the associations of lymphotoxin alpha (LTA) 252 A>G polymorphism (rs909253) with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) risk.
|
25931031 |
2015 |
|
rs909253
|
LTA;LOC100287329
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings suggest that LTA rs909253 and TNF rs1800629 polymorphisms are associated with the risk of T1D both independently and in combination with polymorphic markers in other inflammatory genes, and the analysis of multi-allelic combinations provides valuable insight in the study of polygenic traits.
|
31054364 |
2019 |
|
rs909253
|
LTA;LOC100287329
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
Initially, association with T1D was seen for LT-alpha A1069G (intron A, p=0.011, rs909253) and TNF G(-308)A (p<1x10(-5), rs1800629), but no association was observed for TNF G(-238)A (rs361525).
|
17174749 |
2006 |
|
rs909253
|
LTA;LOC100287329
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The present meta-analysis results suggest that the LTA rs909253 GA genotype is a possible risk factor for developing gastric cancer in the Asian population, especially those with H. pylori infection.
|
22748850 |
2012 |
|
rs909253
|
LTA;LOC100287329
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation |
BEFREE |
TNF-β +252 A>G (rs909253) polymorphism is independently associated with presence of autoantibodies in rheumatoid arthritis patients.
|
31049794 |
2019 |
|
rs1041981
|
LTA;LOC100287329
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 rs1800469) associated with breast cancer risk, mainly among AAs.
|
23996684 |
2014 |
|
rs1041981
|
LTA;LOC100287329
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1041981
|
LTA;LOC100287329
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed significant associations with increased cancer risk for rs1041981 (odd ratio (OR) = 1.15, 99% confidential interval (CI) = 1.07-1.25, P < 0.0001, I(2) = 12.2%), rs2239704 (OR = 1.08, 99% CI = 1.01-1.16, P = 0.021, I(2) = 0.0%) and rs2229094 (OR = 1.28, 99% CI = 1.09-1.50, P = 0.003, I(2) = 0.0%).
|
24349304 |
2013 |
|
rs1041981
|
LTA;LOC100287329
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation |
BEFREE |
The T60N LTA polymorphism is associated with type 2 diabetes and other features of the metabolic syndrome among Caucasian individuals.
|
15729581 |
2005 |
|
rs1041981
|
LTA;LOC100287329
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly reduced frequencies were seen for the carriers of the LTA Thr60Asn polymorphism in patients (OR=0.62; 95% CI=0.42-0.93, P=0.019), suggesting a protective effect on Crohn's disease.
|
16931032 |
2006 |
|
rs1041981
|
LTA;LOC100287329
|
Immunosuppression
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 rs1800469) associated with breast cancer risk, mainly among AAs.
|
23996684 |
2014 |