|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12976445 SNP in miR-125a is associated with the risk of pneumonitis after in lung cancer patients undergoing the radiotherapy by regulating the expression of miR-125a and TGFB1.
|
30302847 |
2019 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Pneumonitis
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12976445 SNP in miR-125a is associated with the risk of pneumonitis after in lung cancer patients undergoing the radiotherapy by regulating the expression of miR-125a and TGFB1.
|
30302847 |
2019 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12976445 SNP in miR-125a is associated with the risk of pneumonitis after in lung cancer patients undergoing the radiotherapy by regulating the expression of miR-125a and TGFB1.
|
30302847 |
2019 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12976445 SNP in miR-125a is associated with the risk of pneumonitis after in lung cancer patients undergoing the radiotherapy by regulating the expression of miR-125a and TGFB1.
|
30302847 |
2019 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
The expression levels of miR‑125a and TGFβ in these samples were determined, and CC genotype samples demonstrated upregulated miR‑125a expression, and downregulated TGFβ protein and mRNA expression compared with samples carrying the minor allele, T. To further investigate the association between the rs12976445 polymorphism and the risk of pneumonitis in patients with lung cancer that received radiotherapy, 534 lung cancer patients diagnosed with pneumonitis and 489lung cancer patients without pneumonitis were recruited. rs12976445 was shown to be significantly associated with the risk of pneumonitis.
|
30132551 |
2018 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Pneumonitis
|
|
0.020 |
GeneticVariation |
BEFREE |
The expression levels of miR‑125a and TGFβ in these samples were determined, and CC genotype samples demonstrated upregulated miR‑125a expression, and downregulated TGFβ protein and mRNA expression compared with samples carrying the minor allele, T. To further investigate the association between the rs12976445 polymorphism and the risk of pneumonitis in patients with lung cancer that received radiotherapy, 534 lung cancer patients diagnosed with pneumonitis and 489lung cancer patients without pneumonitis were recruited. rs12976445 was shown to be significantly associated with the risk of pneumonitis.
|
30132551 |
2018 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
The expression levels of miR‑125a and TGFβ in these samples were determined, and CC genotype samples demonstrated upregulated miR‑125a expression, and downregulated TGFβ protein and mRNA expression compared with samples carrying the minor allele, T. To further investigate the association between the rs12976445 polymorphism and the risk of pneumonitis in patients with lung cancer that received radiotherapy, 534 lung cancer patients diagnosed with pneumonitis and 489lung cancer patients without pneumonitis were recruited. rs12976445 was shown to be significantly associated with the risk of pneumonitis.
|
30132551 |
2018 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation |
BEFREE |
The expression levels of miR‑125a and TGFβ in these samples were determined, and CC genotype samples demonstrated upregulated miR‑125a expression, and downregulated TGFβ protein and mRNA expression compared with samples carrying the minor allele, T. To further investigate the association between the rs12976445 polymorphism and the risk of pneumonitis in patients with lung cancer that received radiotherapy, 534 lung cancer patients diagnosed with pneumonitis and 489lung cancer patients without pneumonitis were recruited. rs12976445 was shown to be significantly associated with the risk of pneumonitis.
|
30132551 |
2018 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
For the rs12976445 polymorphism, genetic associations between the combinational genotype and HT risk were also found in the dominant model and overdominant model.
|
27888002 |
2017 |
|
rs8111742
|
SPACA6;MIRLET7E;MIR125A;MIR99B;SPACA6P-AS
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that let-7e rs8111742 and miR-4795 rs1002765 were associated with the risk of gastric cancer in the H. pylori-positive subgroup.
|
28067243 |
2017 |
|
rs8111742
|
SPACA6;MIRLET7E;MIR125A;MIR99B;SPACA6P-AS
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that let-7e rs8111742 and miR-4795 rs1002765 were associated with the risk of gastric cancer in the H. pylori-positive subgroup.
|
28067243 |
2017 |
|
rs8111742
|
SPACA6;MIRLET7E;MIR125A;MIR99B;SPACA6P-AS
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the miRNAs SNPs (let-7e rs8111742 and miR-4795 rs1002765) might have more superior efficiency when combined with PGC SNPs and/or H. pylori for GC or AG risk than a single SNP on its own.
|
26988755 |
2016 |
|
rs8111742
|
SPACA6;MIRLET7E;MIR125A;MIR99B;SPACA6P-AS
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the miRNAs SNPs (let-7e rs8111742 and miR-4795 rs1002765) might have more superior efficiency when combined with PGC SNPs and/or H. pylori for GC or AG risk than a single SNP on its own.
|
26988755 |
2016 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
We determined that the CC genotype and C allele of the rs12976445 C/T polymorphism were significantly more frequent in patients with HD compared with control subjects (P < 0·05) and in intractable GD compared with GD in remission (P < 0·05).
|
24990808 |
2014 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Further the heterozygous CT of miR-196a2 (rs11614913) (OR-1.88, CI-1.06 to 3.35, p-0.02) and homozygous CC of miR-125a (rs12976445) (OR-2.55, CI -1.15 to 4.65, p-0.03) showed increased risk for prostate cancer.
|
29594807 |
2020 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation |
BEFREE |
Further the heterozygous CT of miR-196a2 (rs11614913) (OR-1.88, CI-1.06 to 3.35, p-0.02) and homozygous CC of miR-125a (rs12976445) (OR-2.55, CI -1.15 to 4.65, p-0.03) showed increased risk for prostate cancer.
|
29594807 |
2020 |
|
rs8111742
|
SPACA6;MIRLET7E;MIR125A;MIR99B;SPACA6P-AS
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs2241490 (upstream of miR-125b-1, G > A, adjusted HR = 1.24, 95%CI = 1.05-1.48, P = 0.014, in dominant model; adjusted HR = 1.18, 95%CI = 1.03-1.35, P = 0.014, in additive model), rs512932 (upstream of miR-125b-1, A > G, dominant model: adjusted HR = 1.25, 95%CI = 1.05-1.48, P = 0.013) and rs8111742 (upstream of miR-125a, G > A, dominant model: adjusted HR = 0.84, 95%CI = 0.71-1.00, P = 0.047) were associated with the prognosis of 1001 Chinese NSCLC patients.
|
30843663 |
2019 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS MicroRNA-125a polymorphism rs12976445 plays a role in AF recurrence via the regulation of IL-6R.
|
30203815 |
2018 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we performed a case-control study using 800 individuals, including 389 patients with CRC and 411 noncancer controls to evaluate the association between miR-30a rs2222722 and miR-125a rs12976445 polymorphisms, located at in the promoter region, and the risk of sporadic CRC in an Iranian population.
|
30387187 |
2018 |
|
rs10404453
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Epistatic interaction by multifactorial dimensionality reduction analysis revealed that the genotypes of the polymorphisms of miR-125a (rs41275794, rs12976445, rs10404453), miR-499a (rs3746444) and LIN28 (rs3811463) were interacting significantly [OR=2.54 (1.65-3.92)], thereby contributing to the risk of chronic periodontitis.
|
28732738 |
2017 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Epistatic interaction by multifactorial dimensionality reduction analysis revealed that the genotypes of the polymorphisms of miR-125a (rs41275794, rs12976445, rs10404453), miR-499a (rs3746444) and LIN28 (rs3811463) were interacting significantly [OR=2.54 (1.65-3.92)], thereby contributing to the risk of chronic periodontitis.
|
28732738 |
2017 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, rs12976445 polymorphism is significantly associated with the risk of IDD in the Chinese population.
|
26800505 |
2016 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Presenile dementia
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed that rs12976445 is significantly associated with the risk of dementia after ischemic stroke.
|
27106952 |
2016 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Dementia
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed that rs12976445 is significantly associated with the risk of dementia after ischemic stroke.
|
27106952 |
2016 |
|
rs12976445
|
SPACA6;MIRLET7E;MIR125A;SPACA6P-AS
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Association Between microRNA-125a rs12976445 C>T Polymorphism and 18F-Fluorodeoxyglucose (18FDG) Uptake: Clinical and Metabolic Response in Patients with Non-Small Cell Lung Cancer.
|
27814341 |
2016 |