|
rs703842
|
CYP27B1;METTL1
|
Multiple Sclerosis
|
|
0.840 |
GeneticVariation |
BEFREE |
No association of rs703842 with MS disability progression or calcidiol serum level was found.
|
30875612 |
2019 |
|
rs703842
|
CYP27B1;METTL1
|
Multiple Sclerosis
|
|
0.840 |
GeneticVariation |
BEFREE |
As a result, we could not perform meta-analysis for assessing the relationship in other ethnic groups.In summary, we found that the genetic variant rs703842 in CYP27B1 is associated with MS risk in Caucasians.
|
27175669 |
2016 |
|
rs703842
|
CYP27B1;METTL1
|
Multiple Sclerosis
|
|
0.840 |
GeneticVariation |
BEFREE |
We found that the frequencies of the A allele of rs703842 were higher in MS patients than controls (p=0.032), and statistical differences were observed in the genotypes of both rs703842 (p=0.013) and rs10876994 (p=0.001) between NMO patients and controls.
|
25542806 |
2015 |
|
rs703842
|
CYP27B1;METTL1
|
Multiple Sclerosis
|
|
0.840 |
GeneticVariation |
BEFREE |
The 'C' allele of CYP27B1 rs703842 was inversely associated with MS risk; this association appeared stronger among HLA-DR15 negative (OR = 0.79, 95% CI: 0.69, 0.90) compared to HLA-DR15 positive individuals (OR = 0.91, 95% CI: 0.80, 1.04).
|
21431378 |
2011 |
|
rs703842
|
CYP27B1;METTL1
|
Multiple Sclerosis
|
A |
0.840 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
19525955 |
2009 |
|
rs703842
|
CYP27B1;METTL1
|
Multiple Sclerosis
|
A |
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
19525955 |
2009 |
|
rs10877012
|
CYP27B1;METTL1
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Individuals carrying the GG genotype of CYP27B1 G > T (rs10877012) exhibited decreased CRC risk compared with those with the TT genotype (OR<sub>adjusted</sub> (OR<sub>adj</sub>) = 0.57, 95% Confidence Interval (CI) = 0.38-0.84).
|
28821819 |
2017 |
|
rs10877012
|
CYP27B1;METTL1
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Dietary habits, lifestyle, and polymorphisms in VDR (ApaI), CYP24A1 (rs6013897, rs158552, rs17217119) and CYP27B1 (rs10877012) were associated with a higher risk of CRC.
|
28009432 |
2017 |
|
rs10877012
|
CYP27B1;METTL1
|
Sarcoidosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Subjects carrying the CC genotype of <i>CYP27B1</i> rs10877012 have 10 times lower odds of suffering from sarcoidosis.
|
31572458 |
2019 |
|
rs3782130
|
CYP27B1;METTL1
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no associations of rs4646537 and rs3782130 with overall cancer risks.
|
31467173 |
2019 |
|
rs3782130
|
CYP27B1;METTL1
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no associations of rs4646537 and rs3782130 with overall cancer risks.
|
31467173 |
2019 |
|
rs703842
|
CYP27B1;METTL1
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>GG</i> genotype of rs2762939 was significantly associated with the risk of ACS development, but not correlated to the vitamin D level. rs4809960 and rs703842 genetic variations were not associated with ACS nor with 25(OH)D level.
|
31398293 |
2019 |
|
rs10877012
|
CYP27B1;METTL1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12794714 and rs10877012 SNPs were associated with asthma risk.
|
29502202 |
2018 |
|
rs10877012
|
CYP27B1;METTL1
|
Chlamydia Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
This study assesses the impact of eight polymorphisms in five genes [VDR (rs1544410 G > A, rs2228570 C > T), CYP27B1 (rs10877012 G > T), DHCR7 (rs7944926 G > A, rs3829251 G > A), GC (rs3755967) and CYP2R1 (rs10741657 G > A, rs2060793 G > A)] on susceptibility to Chlamydia infections in humans.
|
26867646 |
2016 |
|
rs10877013
|
METTL1;EEF1AKMT3
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The MS-associated variant rs10877013 is a genetic determinant that affects the functioning of the vitamin D system linking environmental and genetic factors.
|
26466946 |
2016 |
|
rs3782130
|
CYP27B1;METTL1
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The study suggests that some genetic polymorphisms involved in the vitamin D pathway may associate with NSCLC risk, and one of the polymorphisms (rs3782130) may affect gene expression and patient survival.
|
25544771 |
2015 |
|
rs703842
|
CYP27B1;METTL1
|
Neuromyelitis Optica
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the frequencies of the A allele of rs703842 were higher in MS patients than controls (p=0.032), and statistical differences were observed in the genotypes of both rs703842 (p=0.013) and rs10876994 (p=0.001) between NMO patients and controls.
|
25542806 |
2015 |
|
rs3782130
|
CYP27B1;METTL1
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, no significant difference was observed for VDR (rs2238136), GC (rs4588), CYP2R1 (rs12794714), and CYP27B1 (rs3782130) gene variants in either genotype or allele frequencies between the cases with CRC and the controls and this lack of difference remained even after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC.
|
24568525 |
2014 |
|
rs703842
|
CYP27B1;METTL1
|
Uveitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that the rs703842 A>G polymorphism may play a role in HLA-B27-associated uveitis.
|
23614044 |
2013 |
|
rs10877012
|
CYP27B1;METTL1
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs10877012
|
CYP27B1;METTL1
|
Primary differentiated carcinoma of thyroid gland
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs10877012
|
CYP27B1;METTL1
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D(3) (25[OH]D(3)) and treatment outcome were analysed.
|
22808108 |
2012 |
|
rs10877012
|
CYP27B1;METTL1
|
Differentiated Thyroid Gland Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs10877012
|
CYP27B1;METTL1
|
Follicular thyroid carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs10877012
|
CYP27B1;METTL1
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the CYP27B1-1260 promoter polymorphism rs10877012 had substantial impact on 1,25-dihydroxyvitamin D serum levels (72, 61, and 60 pmol/ml for rs10877012 AA, AC, and CC, respectively, p=0.04) and on SVR rates in HCV genotype 1, 2, and 3 infected patients (77% and 65% versus 42% for rs10877012 AA, AC, and CC, respectively, p=0.02).
|
21145801 |
2011 |