MLH1, mutL homolog 1, 4292

N. diseases: 526; N. variants: 757
Disease: Malignant neoplasm of stomach stage IV ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800734
rs1800734
Entrez Id: 4292;9852
Gene Symbol: MLH1;EPM2AIP1
MLH1;EPM2AIP1
CUI: C0278498
Disease:
Malignant neoplasm of stomach stage IV 		0.010 GeneticVariation BEFREE The present retrospective study enrolled 108 Chinese patients with MGC receiving EOF as first-line chemotherapy, and genotyped six single nucleotide polymorphisms (SNPs) in four hypoxia-associated genes [myoglobin (MB) rs7292 and rs7293, ATP Binding Cassette Subfamily G Member 2 rs2231142, MutL homolog 1 (MLH1) rs1800734 and rs9852810, and Poly(ADP-Ribose) Polymerase 1 rs1136410]. 29399184 2018
dbSNP: rs9852810
rs9852810
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0278498
Disease:
Malignant neoplasm of stomach stage IV 		0.010 GeneticVariation BEFREE The results of the present study demonstrated that the CT/TT genotype of MB rs7292 and the GG genotype of MLH1 rs9852810 were independent favorable predictive factors of PFS in patients with MGC treated with EOF. 29399184 2018