MMP8, matrix metallopeptidase 8, 4317

N. diseases: 213; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1939012
rs1939012
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0014548
Disease:
Epilepsy, Generalized
T 0.700 GeneticVariation GWASCAT Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. 25087078 2014
dbSNP: rs35866072
rs35866072
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.030 GeneticVariation BEFREE MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not participant with the susceptibility of cancer. 31638929 2019
dbSNP: rs35866072
rs35866072
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.030 GeneticVariation BEFREE MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not participant with the susceptibility of cancer. 31638929 2019
dbSNP: rs35866072
rs35866072
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.030 GeneticVariation BEFREE MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan. 30194163 2018
dbSNP: rs35866072
rs35866072
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.030 GeneticVariation BEFREE MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan. 30194163 2018
dbSNP: rs35866072
rs35866072
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.030 GeneticVariation BEFREE MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan. 29599337 2018
dbSNP: rs35866072
rs35866072
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.030 GeneticVariation BEFREE MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan. 29599337 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.020 GeneticVariation BEFREE MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan. 30194163 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan. 30194163 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan. 29599337 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.020 GeneticVariation BEFREE MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan. 29599337 2018
dbSNP: rs11225395
rs11225395
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.010 GeneticVariation BEFREE In conclusion, these findings suggested that the <i>MMP-8</i> rs11225395 polymorphism is associated with elevated susceptibility to cancer</span> in non-Asian populations. 31590330 2019
dbSNP: rs11225395
rs11225395
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.010 GeneticVariation BEFREE In conclusion, these findings suggested that the <i>MMP-8</i> rs11225395 polymorphism is associated with elevated susceptibility to cancer</span> in non-Asian populations. 31590330 2019
dbSNP: rs11225395
rs11225395
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0948008
Disease:
Ischemic stroke
0.010 GeneticVariation BEFREE In conclusion, the present study was the first to identify an association between polymorphism rs11225395 of the MMP8 gene and IS risk. 31056794 2019
dbSNP: rs1940475
rs1940475
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006826
Disease:
Malignant Neoplasms
0.010 GeneticVariation BEFREE MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not participant with the susceptibility of cancer. 31638929 2019
dbSNP: rs1940475
rs1940475
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1306459
Disease:
Primary malignant neoplasm
0.010 GeneticVariation BEFREE MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not participant with the susceptibility of cancer. 31638929 2019
dbSNP: rs11225394
rs11225394
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE In the genetic model analysis, the minor allele "T" of rs11225394 in MMP8 was associated with increased risk of BC under the recessive model (P = 0.019), and the minor allele "A" of rs3787268 was associated with decreased risk of BC under the dominant model (P = 0.014). 30194384 2018
dbSNP: rs11225394
rs11225394
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0678222
Disease:
Breast Carcinoma
0.010 GeneticVariation BEFREE In the genetic model analysis, the minor allele "T" of rs11225394 in MMP8 was associated with increased risk of BC under the recessive model (P = 0.019), and the minor allele "A" of rs3787268 was associated with decreased risk of BC under the dominant model (P = 0.014). 30194384 2018
dbSNP: rs11225395
rs11225395
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE Additionally, the haplotype "AGTCA" constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype "CCG" constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P < 0.05). 30194384 2018
dbSNP: rs11225395
rs11225395
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0678222
Disease:
Breast Carcinoma
0.010 GeneticVariation BEFREE Additionally, the haplotype "AGTCA" constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype "CCG" constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P < 0.05). 30194384 2018
dbSNP: rs1939012
rs1939012
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0042571
Disease:
Vertigo
0.010 GeneticVariation BEFREE Our results suggest that the SNPs rs1939012 and rs1783901 may play a potential role of gene regulation and/or epistasis in a complex etiology of vertigo. 30300896 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0153381
Disease:
Malignant neoplasm of mouth
0.010 GeneticVariation BEFREE Our findings suggest that the polymorphisms at MMP-8 C-799T or Val436Ala may not play a major role in mediating personal risk of oral cancer; however, the detailed mechanisms require further investigation. 28652424 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C4520843
Disease:
Pterygium of eye
0.010 GeneticVariation BEFREE Polymorphisms at MMP-8 -799C/T, Val436Ala and Lys460Thr may not mainly contribute to determining personal susceptibility to pterygium in the Taiwanese examined. 29275297 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C0220641
Disease:
Lip and Oral Cavity Carcinoma
0.010 GeneticVariation BEFREE Our findings suggest that the polymorphisms at MMP-8 C-799T or Val436Ala may not play a major role in mediating personal risk of oral cancer; however, the detailed mechanisms require further investigation. 28652424 2018
dbSNP: rs34009635
rs34009635
Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1867441
Disease:
Pterygium Of Conjunctiva And Cornea
0.010 GeneticVariation BEFREE Polymorphisms at MMP-8 -799C/T, Val436Ala and Lys460Thr may not mainly contribute to determining personal susceptibility to pterygium in the Taiwanese examined. 29275297 2018