|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
This study suggests that NPY rs16147 T and rs16139 C minor alleles are associated with increased risk, whereas the minor allele T of the rs5574 is associated with a reduced risk of obesity.
|
26240981 |
2015 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
Two SNPs (rs17149106 (G>T) and rs16139 (T>C)), with minor allele frequencies of 4%, were associated with elevated risks of obesity (BMI ≥ 30 kg/m(2)) in both cohorts.
|
21937627 |
2011 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
In 6 years follow-up, the polymorphism alone did not change the risk for abnormal glucose regulation, while obesity</span> was associated with a significant 3-fold risk (odds ratio (OR) 2.95; 95% confidence interval (CI) 1.81-4.81, P<0.001) and the Leu7Pro polymorphism-obesity interaction, with a remarkable 12-fold risk (OR 12.33; 95% CI 1.18-128.35, P<0.05).
|
18043699 |
2009 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
The consistent findings among men suggest that the NPY Leu7Pro polymorphism (or another linked marker) might be involved in the development of obesity at younger ages.
|
16568137 |
2006 |
|
rs16147
|
NPY;LOC107986777
|
Obesity
|
|
0.040 |
GeneticVariation |
BEFREE |
Our data indicate that the NPY rs16147 genotypes affect the change in abdominal adiposity in response to dietary interventions, and the effects of the rs16147 single-nucleotide polymorphism on central obesity and abdominal fat distribution were modified by dietary fat.
|
26156739 |
2015 |
|
rs16147
|
NPY;LOC107986777
|
Obesity
|
|
0.040 |
GeneticVariation |
BEFREE |
This study suggests that NPY rs16147 T and rs16139 C minor alleles are associated with increased risk, whereas the minor allele T of the rs5574 is associated with a reduced risk of obesity.
|
26240981 |
2015 |
|
rs16147
|
NPY;LOC107986777
|
Obesity
|
|
0.040 |
GeneticVariation |
BEFREE |
Both rs16147 and rs16131 were associated with the risk of obesity, and the latter was also associated with insulin resistance, triacylglycerols, leptin, and HDL-c.
|
23624317 |
2013 |
|
rs16147
|
NPY;LOC107986777
|
Obesity
|
|
0.040 |
GeneticVariation |
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
rs17149106
|
NPY;LOC107986777
|
Obesity
|
|
0.020 |
GeneticVariation |
BEFREE |
In logistic regression models controlling for gender and obesity, the CT genotype of rs5574 (OR=0.54, 95%CI: 0.30-0.89) and the GT genotype of rs17149106 (OR=5.58, 95%CI: 1.09-28.54) were significantly associated with asthma.
|
27469060 |
2016 |
|
rs17149106
|
NPY;LOC107986777
|
Obesity
|
|
0.020 |
GeneticVariation |
BEFREE |
Two SNPs (rs17149106 (G>T) and rs16139 (T>C)), with minor allele frequencies of 4%, were associated with elevated risks of obesity (BMI ≥ 30 kg/m(2)) in both cohorts.
|
21937627 |
2011 |
|
rs5574
|
NPY;LOC107986777
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that NPY rs16147 T and rs16139 C minor alleles are associated with increased risk, whereas the minor allele T of the rs5574 is associated with a reduced risk of obesity.
|
26240981 |
2015 |
|
rs16131
|
NPY;LOC107986777
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs16147 and rs16131 were associated with the risk of obesity, and the latter was also associated with insulin resistance, triacylglycerols, leptin, and HDL-c.
|
23624317 |
2013 |
|
rs16475
|
NPY;LOC107986777
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Because NPY is a potent orexigenic peptide stimulating food intake, and genetic variation of the gene has been shown to influence development of obesity, we investigated the impact of NPY polymorphisms on antipsychotic-induced BWG.We analyzed 5 polymorphisms in the NPY gene (rs10551063, rs16147, rs5573, rs5574, and rs16475) in schizophrenia subjects (n = 226), treated mostly with clozapine and olanzapine for up to 14 weeks.
|
23277265 |
2013 |