P2RX7, purinergic receptor P2X 7, 5027

N. diseases: 337; N. variants: 23
Disease: Pain ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1718125
rs1718125
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.020 GeneticVariation BEFREE Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer. 30762755 2019
dbSNP: rs7958311
rs7958311
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.020 GeneticVariation BEFREE We tested whether the single-nucleotide polymorphism rs7958311, previously implicated in clinical pain, was associated with experimental and clinical pain phenotypes. 29470314 2018
dbSNP: rs1718125
rs1718125
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.020 GeneticVariation BEFREE In the genotype-based association study, only the rs1718125 G>A SNP tended to be associated with higher pain scores on a visual analog scale 24 h after surgery (VAS24). 25472448 2014
dbSNP: rs7958311
rs7958311
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.020 GeneticVariation BEFREE Moreover, in two independent human chronic pain cohorts, a cohort with pain after mastectomy and a cohort with osteoarthritis, we observed a genetic association between lower pain intensity and the hypofunctional His270 (rs7958311) allele of P2RX7. 22447075 2012
dbSNP: rs1718119
rs1718119
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.010 GeneticVariation BEFREE We further demonstrated that in patients with diabetic peripheral neuropathic pain (DPNP), the presence of the GOF SNPs rs208294 (His155Tyr) and rs1718119 (Ala348Thr) is associated, in females, with higher pain intensity scores. 24934217 2014
dbSNP: rs208294
rs208294
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.010 GeneticVariation BEFREE We further demonstrated that in patients with diabetic peripheral neuropathic pain (DPNP), the presence of the GOF SNPs rs208294 (His155Tyr) and rs1718119 (Ala348Thr) is associated, in females, with higher pain intensity scores. 24934217 2014
dbSNP: rs796590326
rs796590326
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.010 GeneticVariation BEFREE We further demonstrated that in patients with diabetic peripheral neuropathic pain (DPNP), the presence of the GOF SNPs rs208294 (His155Tyr) and rs1718119 (Ala348Thr) is associated, in females, with higher pain intensity scores. 24934217 2014
dbSNP: rs201059543
rs201059543
Entrez Id: 5027;105370032
Gene Symbol: P2RX7;LOC105370032
P2RX7;LOC105370032
CUI: C0030193
Disease:
Pain 		0.010 GeneticVariation BEFREE Using genome-wide linkage analyses, we discovered an association between nerve-injury-induced pain behavior (mechanical allodynia) and the P451L mutation of the mouse P2rx7 gene, such that mice in which P2X7Rs have impaired pore formation as a result of this mutation showed less allodynia than mice with the pore-forming P2rx7 allele. 22447075 2012