DisGeNET - a database of gene-disease associations

NEUROG3, neurogenin 3, 50674

N. diseases: 49; N. variants: 8

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121917837

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C1835888
Disease:

Diarrhea 4, Malabsorptive, Congenital

0.800

GeneticVariation

UNIPROT

Mutant neurogenin-3 in congenital malabsorptive diarrhea.

16855267

2006

dbSNP:

rs121917838

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C1835888
Disease:

Diarrhea 4, Malabsorptive, Congenital

0.800

GeneticVariation

UNIPROT

Mutant neurogenin-3 in congenital malabsorptive diarrhea.

16855267

2006

dbSNP:

rs121917837

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C1835888
Disease:

Diarrhea 4, Malabsorptive, Congenital

0.800

CausalMutation

CLINVAR

dbSNP:

rs121917838

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C1835888
Disease:

Diarrhea 4, Malabsorptive, Congenital

0.800

CausalMutation

CLINVAR

dbSNP:

rs11592899

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C0005890
Disease:

Body Height

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs41277236

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs1461650439

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C1835888
Disease:

Diarrhea 4, Malabsorptive, Congenital

0.700

CausalMutation

CLINVAR

dbSNP:

rs144643855

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C2938940
Disease:

Post stroke depression

0.010

GeneticVariation

BEFREE

The study identified 2 novel genes associated with PSD [HTR3D (rs55674402, p = 0.002512, odds ratio (OR) = 0.7431); NEUROG3 (rs144643855, p = 0.00325, OR = 0.6523)] and 3 risk SNPs in one risk gene associated with non-PSD [PIK3C2B (rs17406271, p = 0.0006801, OR = 1.446; rs2271419, p = 0.0005836, OR = 1.497; rs2271420, p = 0.001031, OR = 1.431)] in the Chinese sample.

31121388

2019

dbSNP:

rs3812704

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.010

GeneticVariation

BEFREE

Variants in USF1, ABCC8, ISL1 and KCNJ11 showed nominal association, while haplotypes in these genes were significantly associated. rs3812704 upstream of NEUROG3 significantly increased risk for type 2 diabetes in normal-weight/lean subjects (OR=1.68 (95%CI 1.25-2.24), P=4.9 × 10(-4)).

21814221

2011

dbSNP:

rs4536103

Entrez Id:	50674;101929021
Gene Symbol:	NEUROG3;LOC101929021

NEUROG3;LOC101929021

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.010

GeneticVariation

BEFREE

Polymorphisms of these genes (Ala45Thr [NEUROD1], Ser199Phe [NEUROG3], and Ala98Val [TCF1]) have been postulated to influence the development of type 2 diabetes.

15277395

2004