We examined whether dietary macronutrient intake modified associations between ANGPTL4[E40K] variation and TG and HDL-C in White men and women from the Atherosclerosis Risk in Communities study.
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
The observed associations suggest that the <i>ANGPTL4</i> variants have a potential role on serum lipid levels and atherosclerosis-related diseases in the Chinese Han population, especially the <i>ANGPTL4</i> rs4076317 and rs2967605 SNPs.