rs3764880
|
TLR8;TLR8-AS1
|
Active tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
rs2407992
|
TLR8;TLR8-AS1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model).
|
18682521 |
2008 |
rs2407992
|
TLR8;TLR8-AS1
|
Bronchiolitis
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization.
|
27498757 |
2016 |
rs3764879
|
TLR8;TLR8-AS1
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.
|
18985439 |
2009 |
rs3764880
|
TLR8;TLR8-AS1
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.
|
18985439 |
2009 |
rs2407992
|
TLR8;TLR8-AS1
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |
rs2407992
|
TLR8;TLR8-AS1
|
Enterovirus Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |
rs3764880
|
TLR8;TLR8-AS1
|
Hemorrhagic Fever, Crimean
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that heterozygous plus homozygous mutant genotypes frequency for TLR8 Met1Val and for TLR9 -1486T/C were significantly higher in CCHF patients than controls (p = 0.038 and p = 0.009, respectively).
|
20674764 |
2010 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
TLR8 rs3764880-G allele was associated with spontaneous HCV clearance in both sexes (P < .0001) albeit with an apparently stronger association in males (OR = 6.02 for men vs 2.2 for women).
|
28752959 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
rs3764879
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.020 |
GeneticVariation |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
rs3764879
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
rs1013151
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
rs5744069
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
rs3764880
|
TLR8;TLR8-AS1
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, TLR8 gene rs3764880 polymorphism might be associated with susceptibility and involved in the inflammatory reaction and lipid metabolism of IS in southern Chinese Han.
|
27772795 |
2016 |
rs3764880
|
TLR8;TLR8-AS1
|
Kidney Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Carrier frequencies of the minor alleles of TLR1 p.His305Leu (OR = 4.79, 95% CI = 2.35-9.75, P = 0.0002), TLR1 p.Asn248Ser (OR = 1.26, 95% CI = 1.07-1.47, P = 0.04) and TLR8 p.Met1Val (OR = 1.37, 95% CI = 1.14-1.64, P = 0.008) were significantly higher in patients with ESRD, with little specificity for the underlying renal disease entity (adjusted for age, gender and donor-recipient relatedness).
|
26445497 |
2015 |
rs3764879
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found.
|
24919757 |
2014 |
rs3764879
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002).
|
26762473 |
2016 |
rs3764880
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032).
|
24445780 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002).
|
26762473 |
2016 |
rs3761624
|
TLR8;TLR8-AS1
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis.
|
31430261 |
2019 |
rs1569113445
|
TLR8;TLR8-AS1
|
OSTEOARTHRITIS SUSCEPTIBILITY 1
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1569113447
|
TLR8;TLR8-AS1
|
OSTEOARTHRITIS SUSCEPTIBILITY 1
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs3764880
|
TLR8;TLR8-AS1
|
Pericardial effusion
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females.
|
24445780 |
2014 |