rs1569113445
|
TLR8;TLR8-AS1
|
OSTEOARTHRITIS SUSCEPTIBILITY 1
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1569113447
|
TLR8;TLR8-AS1
|
OSTEOARTHRITIS SUSCEPTIBILITY 1
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation |
BEFREE |
We found a strong association with genotype A/(-) at rs3764880 with susceptibility to pulmonary TB in males (OR 2.87, 95%CI 1.38-5.98, p=0.007).
|
21846947 |
2011 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, we show an association of SNP TLR8 rs3764880 with PTB in the Moldavian male population, providing support to previous studies conducted on other populations.
|
30529560 |
2019 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
TLR8 rs3764880-G allele was associated with spontaneous HCV clearance in both sexes (P < .0001) albeit with an apparently stronger association in males (OR = 6.02 for men vs 2.2 for women).
|
28752959 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation |
BEFREE |
The AA genotype of rs3764880 SNP was found to increase the risk of PTB among females with an OR of 4.81 (1.11-20.85).
|
30424735 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
rs3764879
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found.
|
24919757 |
2014 |
rs3764879
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.020 |
GeneticVariation |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
rs3764879
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002).
|
26762473 |
2016 |
rs3764879
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7).
|
18927625 |
2008 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032).
|
24445780 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002).
|
26762473 |
2016 |
rs1013151
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
rs2407992
|
TLR8;TLR8-AS1
|
Bronchiolitis
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization.
|
27498757 |
2016 |
rs2407992
|
TLR8;TLR8-AS1
|
Enterovirus Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |
rs2407992
|
TLR8;TLR8-AS1
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |
rs2407992
|
TLR8;TLR8-AS1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model).
|
18682521 |
2008 |
rs3761624
|
TLR8;TLR8-AS1
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis.
|
31430261 |
2019 |
rs3764879
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the GG genotype of SNP rs7873784 in TLR4 (OR = 2.136; 95% CI: 1.312-3.478) and the CC genotype of rs3764879 in TLR8 (OR = 1.982; 95% CI: 1.292-3.042) were also significantly higher in the PTB group than in the HC group.
|
25928077 |
2015 |
rs3764879
|
TLR8;TLR8-AS1
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.
|
18985439 |
2009 |
rs3764879
|
TLR8;TLR8-AS1
|
Pseudohyperkalemia Cardiff
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).
|
29947302 |
2018 |