PLAU, plasminogen activator, urokinase, 5328

N. diseases: 439; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2227564
rs2227564
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE This study investigated associations of a C-to-T polymorphism of uPA (P141L, rs2227564) in exon 6 in 454 Japanese health checkup examinees (126 males and 328 females) aged 35 to 85 without a history of cancer. 21627387 2011
dbSNP: rs4065
rs4065
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0684249
Disease:
Carcinoma of lung 		0.010 GeneticVariation BEFREE Logistic regression analysis revealed that individuals with uPA rs4065 TT genotype have higher odds ratios (ORs) for lung cancer. 20937265 2011
dbSNP: rs4065
rs4065
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0242379
Disease:
Malignant neoplasm of lung 		0.010 GeneticVariation BEFREE Logistic regression analysis revealed that individuals with uPA rs4065 TT genotype have higher odds ratios (ORs) for lung cancer. 20937265 2011
dbSNP: rs4065
rs4065
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C1306460
Disease:
Primary malignant neoplasm of lung 		0.010 GeneticVariation BEFREE Logistic regression analysis revealed that individuals with uPA rs4065 TT genotype have higher odds ratios (ORs) for lung cancer. 20937265 2011
dbSNP: rs4065
rs4065
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.010 GeneticVariation BEFREE Our results revealed that genetic polymorphisms of the uPA rs4065 C/T and uPAR rs344781 (-516 T/C) were associated with the susceptibility and severity of NSCLC. 20937265 2011
dbSNP: rs2227564
rs2227564
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0027051
Disease:
Myocardial Infarction 		0.010 GeneticVariation BEFREE We genotyped rs4065 [3'-UTR (untranslated region) *141C>T) and rs2227564 (Pro141Leu) in the PLAU gene as well as rs344781 (-516T>C) in the PLAUR gene in 633 MI patients and 1237 gender- and age-matched control subjects. 20518747 2010
dbSNP: rs2227564
rs2227564
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C1140680
Disease:
Malignant neoplasm of ovary 		0.010 GeneticVariation BEFREE In order to elucidate the possible role of the Pro121Leu exchange in uPA and the Ala/Thr variants in the signal sequence of PAI-1 in the development and/or progression of human ovarian cancer, we studied the presence of these mutants or variants in a series of 22 ovarian cancer tissues. 9194591 1997
dbSNP: rs2227564
rs2227564
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0919267
Disease:
ovarian neoplasm 		0.010 GeneticVariation BEFREE In order to elucidate the possible role of the Pro121Leu exchange in uPA and the Ala/Thr variants in the signal sequence of PAI-1 in the development and/or progression of human ovarian cancer, we studied the presence of these mutants or variants in a series of 22 ovarian cancer tissues. 9194591 1997
dbSNP: rs2227564
rs2227564
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE In order to elucidate the possible role of the Pro121Leu exchange in uPA and the Ala/Thr variants in the signal sequence of PAI-1 in the development and/or progression of human ovarian cancer, we studied the presence of these mutants or variants in a series of 22 ovarian cancer tissues. 9194591 1997
dbSNP: rs2227564
rs2227564
Entrez Id: 5328;414236
Gene Symbol: PLAU;C10orf55
PLAU;C10orf55
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE In addition to the wild-type sequence, the Pro121Leu exchange in the uPA sequence was detected in 10 out of 22 tumor tissues; 11 tumors carried exclusively the Pro121 allele; in one case exclusively the Leu121 allele was detected. 9194591 1997