|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
|
0.830 |
GeneticVariation |
BEFREE |
Our study aimed to determine whether rs7937 (RAB4B, EGLN2), a top genetic variant in 19q13.2 region identified in genome-wide association studies of COPD, is associated with differential DNA methylation in blood (N = 1490) and gene expression in blood (N = 721) and lungs (N = 1087).
|
29092026 |
2018 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
T |
0.830 |
GeneticVariation |
GWASCAT |
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
|
28166215 |
2017 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
|
0.830 |
GeneticVariation |
BEFREE |
Further haplotype analysis revealed that the "CT" haplotype composed of the mutant allele (C) of rs7937, rs3733829 in the EGLN2 gene, was associated with increased COPD risk (odds ratio =1.55; 95% confidence interval, 1.05-2.31; P=0.029).
|
25609945 |
2015 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
|
0.830 |
GeneticVariation |
GWASCAT |
Genotyping this single nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P = 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV(1) (P = 0.08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017).
|
22080838 |
2012 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
|
0.830 |
GeneticVariation |
GWASDB |
Genotyping this single nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P = 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV(1) (P = 0.08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017).
|
22080838 |
2012 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
|
0.830 |
GeneticVariation |
BEFREE |
Genotyping this single nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P = 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV(1) (P = 0.08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017).
|
22080838 |
2012 |
|
rs2604909
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs17726276
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Blood Protein Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Forced expiratory volume function
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation |
GWASDB |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
rs771011224
|
MIA;RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
T34A-C84A-dNSur-His is also a potential therapeutic agent for augmenting cancer therapy.
|
31004782 |
2019 |
|
rs771011224
|
MIA;RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
T34A-C84A-dNSur-His is also a potential therapeutic agent for augmenting cancer therapy.
|
31004782 |
2019 |
|
rs2604894
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping this single nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P = 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV(1) (P = 0.08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017).
|
22080838 |
2012 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine).
|
21862624 |
2011 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine).
|
21862624 |
2011 |
|
rs7937
|
RAB4B;MIA-RAB4B;RAB4B-EGLN2
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine).
|
21862624 |
2011 |