DisGeNET - a database of gene-disease associations

CNNM2, cyclin and CBS domain divalent metal cation transport mediator 2, 54805

N. diseases: 91; N. variants: 24

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0036341
Disease:

Schizophrenia

0.830

GeneticVariation

BEFREE

We investigated the 10q24.32 locus and discovered a 339-bp <i>Alu</i> insertion polymorphism (rs71389983) in complete linkage disequilibrium (LD) with the schizophrenia GWAS risk variant rs7914558.

31840948

2020

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0036341
Disease:

Schizophrenia

0.830

GeneticVariation

BEFREE

Although the biological role of CNNM2 in schizophrenia remains unknown, these data suggest that this CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition.

24311551

2014

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0036341
Disease:

Schizophrenia

0.830

GeneticVariation

GWASCAT

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

23453885

2013

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0036341
Disease:

Schizophrenia

0.830

GeneticVariation

BEFREE

Recently, a new schizophrenia susceptibility locus 10q24.32-q24.33, containing two single-nucleotide polymorphisms (SNPs: rs7914558 and rs11191580), was identified in a genome-wide association study.

22520855

2012

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0036341
Disease:

Schizophrenia

0.830

GeneticVariation

GWASCAT

Genome-wide association study identifies five new schizophrenia loci.

21926974

2011

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0036341
Disease:

Schizophrenia

0.830

GeneticVariation

GWASDB

Genome-wide association study identifies five new schizophrenia loci.

21926974

2011

dbSNP:

rs12413409

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0010068
Disease:

Coronary heart disease

0.800

GeneticVariation

GWASCAT

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

24262325

2014

dbSNP:

rs794726858

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

GeneticVariation

CLINVAR

CNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemia.

24699222

2014

dbSNP:

rs1890185

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0149931
Disease:

Migraine Disorders

0.800

GeneticVariation

GWASCAT

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

23793025

2013

dbSNP:

rs1890185

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0149931
Disease:

Migraine Disorders

0.800

GeneticVariation

GWASDB

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

23793025

2013

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C1263846
Disease:

Attention deficit hyperactivity disorder

0.800

GeneticVariation

GWASCAT

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

23453885

2013

dbSNP:

rs7914558

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C1263846
Disease:

Attention deficit hyperactivity disorder

0.800

GeneticVariation

GWASDB

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

23453885

2013

dbSNP:

rs12413409

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0010068
Disease:

Coronary heart disease

0.800

GeneticVariation

GWASDB

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

21378990

2011

dbSNP:

rs12413409

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0010068
Disease:

Coronary heart disease

0.800

GeneticVariation

GWASCAT

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

21378990

2011

dbSNP:

rs387906975

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C3151295
Disease:

HYPOMAGNESEMIA 6, RENAL

0.800

GeneticVariation

UNIPROT

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia.

21397062

2011

dbSNP:

rs12413409

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0007766
Disease:

Intracranial Aneurysm

0.800

GeneticVariation

GWASCAT

Genome-wide association study of intracranial aneurysm identifies three new risk loci.

20364137

2010

dbSNP:

rs12413409

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0007766
Disease:

Intracranial Aneurysm

0.800

GeneticVariation

GWASDB

Genome-wide association study of intracranial aneurysm identifies three new risk loci.

20364137

2010

dbSNP:

rs387906975

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C3151295
Disease:

HYPOMAGNESEMIA 6, RENAL

0.800

CausalMutation

CLINVAR

dbSNP:

rs786205909

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

CausalMutation

CLINVAR

dbSNP:

rs786205909

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

GeneticVariation

UNIPROT

dbSNP:

rs786205910

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

CausalMutation

CLINVAR

dbSNP:

rs786205910

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

GeneticVariation

UNIPROT

dbSNP:

rs794726858

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

GeneticVariation

UNIPROT

dbSNP:

rs794726858

Entrez Id:	54805;107984265
Gene Symbol:	CNNM2;LOC107984265

CNNM2;LOC107984265

CUI:	C4225333
Disease:

HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION

0.800

CausalMutation

CLINVAR

dbSNP:

rs11191548

Entrez Id:	54805
Gene Symbol:	CNNM2

CNNM2

CUI:	C0020538
Disease:

Hypertensive disease

0.780

GeneticVariation

GWASCAT

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

30487518

2018