DCP1A, decapping mRNA 1A, 55802

N. diseases: 9; N. variants: 1
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11551405
rs11551405
Entrez Id: 55802;107986087
Gene Symbol: DCP1A;LOC107986087
DCP1A;LOC107986087
CUI: C0025202
Disease:
melanoma 		0.020 GeneticVariation BEFREE Our previous study identified that rs11551405 A allele located at the 3' UTR of mRNA-decapping enzyme 1a (DCP1A) was associated with an increased risk for malignant melanoma (MM). 29076924 2018
dbSNP: rs11551405
rs11551405
Entrez Id: 55802;107986087
Gene Symbol: DCP1A;LOC107986087
DCP1A;LOC107986087
CUI: C0025202
Disease:
melanoma 		0.020 GeneticVariation BEFREE The rs11551405 A allele, located at the 3' UTR microRNA binding site of DCP1A, was associated with an increased risk of melanoma disease-specific death in both discovery dataset [adjusted Hazards ratio (HR) = 1.66, 95% confidence interval (CI) = 1.21-2.27, p =1.50 × 10<sup>-3</sup> ] and validation dataset (HR = 1.55, 95% CI = 1.03-2.34, p = 0.038), compared with the C allele, and their meta-analysis showed an HR of 1.62 (95% CI, 1.26-2.08, p =1.55 × 10<sup>-4</sup> ). 27578485 2016