|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Skin lesion
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that Met287Thr influences the susceptibility to premalignant As skin lesions and might be at increased risk for other adverse health effects of iAs exposure.
|
19538983 |
2009 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Precancerous Conditions
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that Met287Thr influences the susceptibility to premalignant As skin lesions and might be at increased risk for other adverse health effects of iAs exposure.
|
19538983 |
2009 |
|
rs3740393
|
AS3MT;BORCS7-ASMT
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
The change in MMA% was linked to individual cancer susceptibility related to AS3MT rs3740393.
|
19680750 |
2009 |
|
rs3740393
|
AS3MT;BORCS7-ASMT
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The change in MMA% was linked to individual cancer susceptibility related to AS3MT rs3740393.
|
19680750 |
2009 |
|
rs1046778
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Schizophrenia
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
|
21791550 |
2011 |
|
rs10748835
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study was to determine if coronary heart disease, hypertension, and hyperlipidemia were associated with low-level arsenic exposure and AS3MT gene single nucleotide polymorphism (SNP) A35991G (rs10748835) in rural Texas.
|
22341486 |
2012 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure).
|
22747749 |
2012 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure).
|
22747749 |
2012 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure).
|
22747749 |
2012 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure).
|
22747749 |
2012 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure).
|
22747749 |
2012 |
|
rs11191439
|
AS3MT;BORCS7-ASMT
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure).
|
22747749 |
2012 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Attention deficit hyperactivity disorder
|
|
0.810 |
GeneticVariation |
GWASDB |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Attention deficit hyperactivity disorder
|
|
0.810 |
GeneticVariation |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
rs7085104
|
AS3MT;BORCS7-ASMT
|
Schizophrenia
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
rs7085104
|
AS3MT;BORCS7-ASMT
|
Schizophrenia
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
rs11191447
|
AS3MT;BORCS7-ASMT
|
Coronary Artery Disease
|
|
0.700 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Bipolar Disorder
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Child Development Disorders, Pervasive
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Schizophrenia
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
rs12416687
|
AS3MT;BORCS7-ASMT
|
Mean blood pressure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
|
24954895 |
2014 |
|
rs12416687
|
AS3MT;BORCS7-ASMT
|
Blood Pressure
|
T |
0.700 |
GeneticVariation |
GWASDB |
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
|
24954895 |
2014 |
|
rs11191454
|
AS3MT;BORCS7-ASMT;LOC107984265
|
Attention deficit hyperactivity disorder
|
|
0.810 |
GeneticVariation |
BEFREE |
Our results provide preliminary evidence for the overtransmission of the A allele at the AS3MT rs11191454 polymorphism in ADHD.
|
25461954 |
2015 |
|
rs3740393
|
AS3MT;BORCS7-ASMT
|
Meningomyelocele
|
|
0.010 |
GeneticVariation |
BEFREE |
Drinking water inorganic arsenic concentration was associated with increased risk of myelomeningocele for participants with 4 of the 14 studied single-nucleotide polymorphisms in genes involved in folate metabolism: the AA/AG genotype of rs2236225 (MTHFD1), the GG genotype of rs1051266 (SLC19A1), the TT genotype of rs7560488 (DNMT3A), and the GG genotype of rs3740393 (AS3MT) with adjusted odds ratio of 1.13, 1.31, 1.20, and 1.25 for rs2236225, rs1051266, rs7560488, and rs3740393, respectively.
|
26250961 |
2015 |