The association remained significant in the subgroup analysis by age (≤60), sex (male), tumor size (≤5 cm), histologic type (diffuse), lymph node metastasis (N0), distant metastasis (M0), and TNM stage (I/II).<b>Conclusions:</b> Our results suggested that the <i>miR-146b</i> rs1536309 polymorphism may be a potential biomarker for the prognosis of gastric cancer.<b>Impact:</b> This is the first evidence showing that patients carrying the <i>miR-146b-5p</i> rs1536309 CC/CT genotypes exhibited better survival than those carrying the TT genotype, suggesting the protective effect of the C allele in the prognosis of gastric cancer.
The association remained significant in the subgroup analysis by age (≤60), sex (male), tumor size (≤5 cm), histologic type (diffuse), lymph node metastasis (N0), distant metastasis (M0), and TNM stage (I/II).<b>Conclusions:</b> Our results suggested that the <i>miR-146b</i> rs1536309 polymorphism may be a potential biomarker for the prognosis of gastric cancer.<b>Impact:</b> This is the first evidence showing that patients carrying the <i>miR-146b-5p</i> rs1536309 CC/CT genotypes exhibited better survival than those carrying the TT genotype, suggesting the protective effect of the C allele in the prognosis of gastric cancer.
The association remained significant in the subgroup analysis by age (≤60), sex (male), tumor size (≤5 cm), histologic type (diffuse), lymph node metastasis (N0), distant metastasis (M0), and TNM stage (I/II).<b>Conclusions:</b> Our results suggested that the <i>miR-146b</i> rs1536309 polymorphism may be a potential biomarker for the prognosis of gastric cancer.<b>Impact:</b> This is the first evidence showing that patients carrying the <i>miR-146b-5p</i> rs1536309 CC/CT genotypes exhibited better survival than those carrying the TT genotype, suggesting the protective effect of the C allele in the prognosis of gastric cancer.
The association remained significant in the subgroup analysis by age (≤60), sex (male), tumor size (≤5 cm), histologic type (diffuse), lymph node metastasis (N0), distant metastasis (M0), and TNM stage (I/II).<b>Conclusions:</b> Our results suggested that the <i>miR-146b</i> rs1536309 polymorphism may be a potential biomarker for the prognosis of gastric cancer.<b>Impact:</b> This is the first evidence showing that patients carrying the <i>miR-146b-5p</i> rs1536309 CC/CT genotypes exhibited better survival than those carrying the TT genotype, suggesting the protective effect of the C allele in the prognosis of gastric cancer.
The association remained significant in the subgroup analysis by age (≤60), sex (male), tumor size (≤5 cm), histologic type (diffuse), lymph node metastasis (N0), distant metastasis (M0), and TNM stage (I/II).<b>Conclusions:</b> Our results suggested that the <i>miR-146b</i> rs1536309 polymorphism may be a potential biomarker for the prognosis of gastric cancer.<b>Impact:</b> This is the first evidence showing that patients carrying the <i>miR-146b-5p</i> rs1536309 CC/CT genotypes exhibited better survival than those carrying the TT genotype, suggesting the protective effect of the C allele in the prognosis of gastric cancer.