Six miR-SNPs in miRNA processing machinery genes, including Dicer (rs3742330), RAN (rs14035), XPO5 (rs11077), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), were evaluated for their association with esophageal squamous cell carcinoma (ESCC).
<b>Methods:</b> We conducted a case-control study in genotyping of five polymorphic loci, including <i>RAN</i> rs14035, <i>XPO5</i> rs11077, <i>DICER1</i> rs13078, <i>DICER1</i> rs3742330, and <i>TARBP2</i> rs784567, in miRNA processing genes to explore the risk factors for T2DM and diabetic vascular complications.
Another three-factor [<i>RAN</i> rs14035, hypertension (HP), and duration of T2DM (DOD)] interaction model was found for macrovascular complications of T2DM (<i>OR</i> = 41.60, 95%CI = 11.75-147.35, <i>P</i> < 0.001).
In this study, we aimed to evaluate the polymorphic variants of miRNA processing genes, RAN (rs14035) and GEMIN3 (rs197388), and their association with a risk of primary open-angle glaucoma (POAG) in relation to selected clinical parameters.
Five single nucleotide polymorphisms (SNPs), including Ran-GTP (<i>RAN</i>) rs14035, exportin-5 (<i>XPO5</i>) rs11077, <i>DICER1</i> rs3742330, <i>DICER1</i> rs13078, and <i>TARBP2</i> rs784567, were genotyped in a case-control study to estimate risk factors of cervical precancerous lesions.
In multivariate Cox proportional hazard regression models, a significant association was found between <i>RAN</i> rs14035 and survival of large artery disease patients with ischemic stroke (CC vs. TT: adjusted hazard ratio, 5.978; <i>P</i>=0.015).
In multivariate Cox proportional hazard regression models, a significant association was found between <i>RAN</i> rs14035 and survival of large artery disease patients with ischemic stroke (CC vs. TT: adjusted hazard ratio, 5.978; <i>P</i>=0.015).
Although we found no direct association between DICER (rs3742330 and rs13078), DROSHA (rs10719 and rs6877842), RAN (rs14035</span>) or XPO5 (rs11077) polymorphisms and HCC risk, we demonstrated that DICER (rs3742330) and RAN (rs14035) were associated with the survival of HCC patients.
In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate.
In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate.
Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer.
Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer.
A haplotype-based analysis of seven polymorphisms of the microRNA machinery genes for gene-gene interactions suggests that ***ACTA, ***GCCA, ***G*C*, *T*ATTA, and ***ACT* haplotypes (asterisk indicates SNP locus not included; DROSHA rs6877842 and rs10719, DICER1 rs13078 and rs3742330, RAN rs14035, and XPO5 rs2257082 and rs11077 polymorphisms) are associated with higher POI prevalence, and that ***GCTA, ***ACCA, *C*ATTA, and *C*ATT* haplotypes are associated with lower POI prevalence.