SENP2, SUMO specific peptidase 2, 59343

N. diseases: 49; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13081203
rs13081203
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		0.700 GeneticVariation GWASCAT Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. 30604766 2019
dbSNP: rs13081203
rs13081203
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		G 0.700 GeneticVariation GWASCAT Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis. 31015462 2019
dbSNP: rs4687477
rs4687477
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs6762208
rs6762208
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.700 GeneticVariation GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382 2018
dbSNP: rs7638853
rs7638853
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0429087
Disease:
Electrocardiogram: P-R interval 		A 0.700 GeneticVariation GWASCAT PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. 30046033 2018
dbSNP: rs12374077
rs12374077
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0428883
Disease:
Diastolic blood pressure 		C 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 28135244 2017
dbSNP: rs4686683
rs4686683
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0428883
Disease:
Diastolic blood pressure 		T 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs6762208
rs6762208
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE In the present study, we evaluated the association of SENPs polymorphism with susceptibility as well as clinicopathologic features and patients' response of breast cancer (BC) in a Chinese population.We genotyped SENP1 (rs61918808), SENP2 (rs6762208), SENP7 (rs61697963) by sequencing in a case-control study including 210 BC patients and 225 healthy volunteers. 30732133 2019
dbSNP: rs6762208
rs6762208
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE In the present study, we evaluated the association of SENPs polymorphism with susceptibility as well as clinicopathologic features and patients' response of breast cancer (BC) in a Chinese population.We genotyped SENP1 (rs61918808), SENP2 (rs6762208), SENP7 (rs61697963) by sequencing in a case-control study including 210 BC patients and 225 healthy volunteers. 30732133 2019
dbSNP: rs6762208
rs6762208
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE The aim of these studies was to investigate an association between polymorphic variants (SNPs) of the SENP1 gene (c.1691 + 36C > T, rs12297820) and SENP2 gene (c.902C > A, p.Thr301Lys, rs6762208) and a risk of breast cancer occurrence. 27178176 2016
dbSNP: rs6762208
rs6762208
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE The aim of these studies was to investigate an association between polymorphic variants (SNPs) of the SENP1 gene (c.1691 + 36C > T, rs12297820) and SENP2 gene (c.902C > A, p.Thr301Lys, rs6762208) and a risk of breast cancer occurrence. 27178176 2016
dbSNP: rs6762208
rs6762208
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C0686619
Disease:
Secondary malignant neoplasm of lymph node 		0.010 GeneticVariation BEFREE SENP2 rs6762208(C>A) was correlated with increasing risk of lymph node metastases (P < .05). 30732133 2019