BCL2, BCL2 apoptosis regulator, 596

N. diseases: 1456; N. variants: 27
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12454712
rs12454712
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
dbSNP: rs4987852
rs4987852
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		0.800 GeneticVariation GWASDB Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs4987852
rs4987852
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		0.800 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs12454712
rs12454712
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0205682
Disease:
Waist-Hip Ratio 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12454712
rs12454712
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs17758695
rs17758695
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0200638
Disease:
Eosinophil count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs17758695
rs17758695
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs17758695
rs17758695
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0014772
Disease:
Red Blood Cell Count measurement 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs17758695
rs17758695
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs4987852
rs4987852
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0855095
Disease:
Small Lymphocytic Lymphoma 		0.700 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs4987867
rs4987867
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs4987867
rs4987867
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs4987867
rs4987867
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs8094630
rs8094630
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C2985280
Disease:
Blood Protein Measurement 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.060 GeneticVariation BEFREE A regulatory (-938C>A, rs2279115) single-nucleotide polymorphism in the inhibitory P2 BCL-2 gene promoter generates significantly different BCL-2 promoter activities and has been associated with different clinical outcomes in various malignancies. 25257838 2015
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.060 GeneticVariation BEFREE Our results indicate that the BCL-2 rs2279115 genetic variant was associated with SCLC risk in Chinese populations and support the hypothesis that SNPs in regulatory regions of oncogenes might contribute to cancer susceptibility. 26311051 2016
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.060 GeneticVariation BEFREE A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. 28396899 2017
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.060 GeneticVariation BEFREE This meta-analysis was performed to evaluate the relationships of Bcl-2 -938 C>A polymorphism (rs2279115) with susceptibility and prognosis of cancer. 25430556 2014
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.060 GeneticVariation BEFREE Simultaneously, rs2279115 was correlated with a significantly higher risk of cancer prognosis in Asia but not in Caucasian. 28445963 2017
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.060 GeneticVariation BEFREE Multiple functional BCL-2 genetic polymorphisms, such as rs2279115, rs1801018 and rs1564483, have been identified previously and might be involved in cancer development through deregulating BCL-2 expression. 26132559 2015
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.050 GeneticVariation BEFREE A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. 28396899 2017
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.050 GeneticVariation BEFREE This meta-analysis was performed to evaluate the relationships of Bcl-2 -938 C>A polymorphism (rs2279115) with susceptibility and prognosis of cancer. 25430556 2014
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.050 GeneticVariation BEFREE Multiple functional BCL-2 genetic polymorphisms, such as rs2279115, rs1801018 and rs1564483, have been identified previously and might be involved in cancer development through deregulating BCL-2 expression. 26132559 2015
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.050 GeneticVariation BEFREE Simultaneously, rs2279115 was correlated with a significantly higher risk of cancer prognosis in Asia but not in Caucasian. 28445963 2017
dbSNP: rs2279115
rs2279115
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.050 GeneticVariation BEFREE Our results indicate that the BCL-2 rs2279115 genetic variant was associated with SCLC risk in Chinese populations and support the hypothesis that SNPs in regulatory regions of oncogenes might contribute to cancer susceptibility. 26311051 2016