BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Disease: Abnormal behavior ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice. 30992540 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders. 30998730 2019
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice. 30992540 2019
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders. 30998730 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders. 29288952 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders. 29288952 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive. 27267363 2016
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults. 26830347 2016
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults. 26830347 2016
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive. 27267363 2016
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity. 24708359 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. 26503495 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity. 24708359 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. 26503495 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies. 24051499 2013
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies. 24051499 2013
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely. 19896331 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE A single nucleotide polymorphism (val66met) in the brain derived neurotrophic factor (BDNF) gene has been shown to be a risk factor for a number of psychiatric disorders, including schizophrenia. 20957650 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein. 19603419 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein. 19603419 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE G196A, a common polymorphism of the BDNF gene, not only affects cognitive and motor processes, but also is associated with various psychiatric disorders. 20085561 2010
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely. 19896331 2010
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0233514
Disease:
Abnormal behavior 		0.100 GeneticVariation BEFREE A single nucleotide polymorphism (val66met) in the brain derived neurotrophic factor (BDNF) gene has been shown to be a risk factor for a number of psychiatric disorders, including schizophrenia. 20957650 2010