The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10<sup>-4</sup> ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 × 10<sup>-9</sup> ; OR, 1.12; 95% CI, 1.08-1.16).
The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10<sup>-4</sup> ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 × 10<sup>-9</sup> ; OR, 1.12; 95% CI, 1.08-1.16).
The combined analysis identified a new risk association for CRC at 2q35 marked by rs992157 (P = 3.15 × 10<sup>-8</sup>, odds ratio = 1.10, 95% confidence interval = 1.06-1.13), which is intronic to PNKD (paroxysmal non-kinesigenic dyskinesia) and TMBIM1 (transmembrane BAX inhibitor motif containing 1).