TIMP4, TIMP metallopeptidase inhibitor 4, 7079

N. diseases: 108; N. variants: 1
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0085215
Disease:
Ovarian Failure, Premature 		0.010 GeneticVariation BEFREE The TIMP1T > C (rs4898), TIMP1G > A (rs6609533), TIMP2G > C (rs8179090), TIMP2G > A (rs2277698), TIMP3G > A (rs135029), and TIMP4T > C (rs3755724) genotypes, but especially the TIMP2 genotypes, were found more frequently in POI patients than in control subjects. 30583769 2019
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0025322
Disease:
Premature Menopause 		0.010 GeneticVariation BEFREE The aim of our study was to investigate whether the TIMP polymorphisms TIMP1T > C (rs4898), TIMP1G > A (rs6609533), TIMP2G > C (rs8179090), TIMP2G > A (rs2277698), TIMP3G > A (rs135029), and TIMP4T > C (rs3755724), which regulate matrix metalloproteinases (MMPs), confer a risk for primary ovarian insufficiency (POI) in Korean women (further studies would be required to evaluate the associations between TIMP polymorphisms and POI in other populations). 30583769 2019
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0036572
Disease:
Seizures 		0.010 GeneticVariation BEFREE This study provides evidence that the promoter TIMP4 rs3755724 is a new focal epilepsy susceptibility variant that is plausibly involved in inflammation-induced seizures in Malaysian Chinese. 25595263 2015
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0014544
Disease:
Epilepsy 		0.010 GeneticVariation BEFREE No significant association was found between rs2920502 and rs3773364-rs3755724-rs2920502 haplotypes for susceptibility to epilepsy in each ethnicity. 25595263 2015
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0014547
Disease:
Epilepsies, Partial 		0.010 GeneticVariation BEFREE Contribution of TIMP4 rs3755724 polymorphism to susceptibility to focal epilepsy in Malaysian Chinese. 25595263 2015
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women. 24903383 2014
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0036341
Disease:
Schizophrenia 		0.010 GeneticVariation BEFREE In the analysis of clinical features of schizophrenia, rs3755724 was nominally associated with schizophrenia with poor concentration (P=0.044 in the codominant2 model, P=0.041 in the log-additive model and P=0.043 in allele frequency). 23229788 2013
dbSNP: rs3755724
rs3755724
Entrez Id: 6854;7079
Gene Symbol: SYN2;TIMP4
SYN2;TIMP4
CUI: C0026691
Disease:
Mucocutaneous Lymph Node Syndrome 		0.010 GeneticVariation BEFREE The minor allele (C) of rs3755724 showed the susceptibility of CALs to risk in KD pati</span>ents. 19048177 2009