<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
More importantly, haplotype analysis revealed that four haplotypes, AC, GT, GC, and AT (rs4986790, rs4986791), were significantly associated with HCV infection when compared with control subjects.
After a multivariate analysis, HCV co-infection (OR= 3.8; 95% CI [2.2-6.5]), baseline CD4 count (OR= 0.996; 95% CI [0.994-0.998]), TLR4 Asp299Gly</span> (OR= 2.57; 95% CI [1.18-5.61]) were independently associated with active TB and inversely with latent TB prophylaxis (OR= 0.24; 95% CI [0.01-0.60]).
<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
Finally, the miRNA target was predicted and annotated to suggest the possible relationship between polymorphism and HCV infection.<b>Results:</b> Our meta-analysis incorporated seven studies involving rs4986791, rs4986790 and rs2149356.
More importantly, haplotype analysis revealed that four haplotypes, AC, GT, GC, and AT (rs4986790, rs4986791), were significantly associated with HCV infection when compared with control subjects.