WFS1, wolframin ER transmembrane glycoprotein, 7466

N. diseases: 185; N. variants: 80
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4689388
rs4689388
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.820 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
dbSNP: rs4689388
rs4689388
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation BEFREE A recent T2D GWAS revealed an association signal (rs4689388) upstream of the gene encoding Wolfram syndrome 1 (WFS1) whose intrinsic nucleotide variants had been previously associated with T2D in several candidate gene analyses. 25800097 2016
dbSNP: rs4689388
rs4689388
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation BEFREE Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897). 23144361 2012
dbSNP: rs4689388
rs4689388
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation GWASDB Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. 21647700 2011
dbSNP: rs4689388
rs4689388
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.820 GeneticVariation GWASCAT Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900 2009
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.810 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.810 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278 2013
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.810 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.810 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.810 GeneticVariation BEFREE Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897). 23144361 2012
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.810 GeneticVariation GWASCAT Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827 2010
dbSNP: rs1801214
rs1801214
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.810 GeneticVariation GWASDB Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827 2010
dbSNP: rs104893882
rs104893882
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C1833021
Disease:
DEAFNESS, AUTOSOMAL DOMINANT 6 		0.800 GeneticVariation UNIPROT Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss. 25388789 2014
dbSNP: rs104893882
rs104893882
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C1833021
Disease:
DEAFNESS, AUTOSOMAL DOMINANT 6 		0.800 GeneticVariation UNIPROT WFS1 and non-syndromic low-frequency sensorineural hearing loss: a novel mutation in a Portuguese case. 24462758 2014
dbSNP: rs104893883
rs104893883
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C1833021
Disease:
DEAFNESS, AUTOSOMAL DOMINANT 6 		0.800 GeneticVariation UNIPROT WFS1 and non-syndromic low-frequency sensorineural hearing loss: a novel mutation in a Portuguese case. 24462758 2014
dbSNP: rs104893883
rs104893883
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C1833021
Disease:
DEAFNESS, AUTOSOMAL DOMINANT 6 		0.800 GeneticVariation UNIPROT Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss. 25388789 2014
dbSNP: rs4458523
rs4458523
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.800 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs4458523
rs4458523
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.800 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs372855769
rs372855769
Entrez Id: 7466;107986257
Gene Symbol: WFS1;LOC107986257
WFS1;LOC107986257
CUI: C4551693
Disease:
Wolfram Syndrome 1 		0.800 GeneticVariation UNIPROT Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease. 22226368 2012
dbSNP: rs4458523
rs4458523
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.800 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs4458523
rs4458523
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs104893882
rs104893882
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C1833021
Disease:
DEAFNESS, AUTOSOMAL DOMINANT 6 		0.800 GeneticVariation UNIPROT Identification of two novel missense WFS1 mutations, H696Y and R703H, in patients with non-syndromic low-frequency sensorineural hearing loss. 21356526 2011
dbSNP: rs104893883
rs104893883
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C1833021
Disease:
DEAFNESS, AUTOSOMAL DOMINANT 6 		0.800 GeneticVariation UNIPROT Identification of two novel missense WFS1 mutations, H696Y and R703H, in patients with non-syndromic low-frequency sensorineural hearing loss. 21356526 2011
dbSNP: rs372855769
rs372855769
Entrez Id: 7466;107986257
Gene Symbol: WFS1;LOC107986257
WFS1;LOC107986257
CUI: C4551693
Disease:
Wolfram Syndrome 1 		0.800 GeneticVariation UNIPROT Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. 21538838 2011
dbSNP: rs387906930
rs387906930
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
CUI: C3280358
Disease:
Wolfram-Like Syndrome, Autosomal Dominant 		0.800 GeneticVariation UNIPROT Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. 21538838 2011