|
rs886037913
|
MAPKAPK3
|
MACULAR DYSTROPHY, PATTERNED, 3
|
|
0.700 |
GeneticVariation |
UNIPROT |
A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.
|
26744326 |
2016 |
|
rs375412266
|
MAPKAPK3
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs414171
|
CISH;MAPKAPK3
|
Susceptibility to tuberculosis
|
T |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs414171
|
CISH;MAPKAPK3
|
BACTEREMIA, SUSCEPTIBILITY TO, 2
|
T |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs414171
|
CISH;MAPKAPK3
|
MALARIA, SUSCEPTIBILITY TO (finding)
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs414171
|
CISH;MAPKAPK3
|
Tuberculosis
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis.
|
24632804 |
2014 |
|
rs414171
|
CISH;MAPKAPK3
|
Tuberculosis
|
|
0.030 |
GeneticVariation |
BEFREE |
The results of the case-control study showed that the C allele of rs2239751 and the T allele of rs414171 are associated with TB susceptibility, and this association exists only in women and young adults.
|
25460819 |
2014 |
|
rs414171
|
CISH;MAPKAPK3
|
Tuberculosis
|
|
0.030 |
GeneticVariation |
BEFREE |
The AA genotypes of the SNPs rs2239751 and rs414171 were significantly associated with TB.
|
23949851 |
2014 |
|
rs2239751
|
CISH;MAPKAPK3
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of the case-control study showed that the C allele of rs2239751 and the T allele of rs414171 are associated with TB susceptibility, and this association exists only in women and young adults.
|
25460819 |
2014 |
|
rs2239751
|
CISH;MAPKAPK3
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
The AA genotypes of the SNPs rs2239751 and rs414171 were significantly associated with TB.
|
23949851 |
2014 |
|
rs414171
|
CISH;MAPKAPK3
|
Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
The CISH rs414171 polymorphism is associated significantly with susceptibility to sepsis and MODS in traumatic patients, which might prove to be a novel biomarker for indicating risk of infectious outcomes in critically injured patients.
|
29920655 |
2018 |
|
rs414171
|
CISH;MAPKAPK3
|
Septicemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The CISH rs414171 polymorphism is associated significantly with susceptibility to sepsis and MODS in traumatic patients, which might prove to be a novel biomarker for indicating risk of infectious outcomes in critically injured patients.
|
29920655 |
2018 |
|
rs2239751
|
CISH;MAPKAPK3
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was observed between CISH rs2239751 polymorphism and risk/protection of PTB.
|
27266592 |
2017 |
|
rs414171
|
CISH;MAPKAPK3
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicated that CISH rs414171 and rs6768300 variants might be associated with protection from PTB.
|
27266592 |
2017 |
|
rs6768300
|
CISH;MAPKAPK3
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicated that CISH rs414171 and rs6768300 variants might be associated with protection from PTB.
|
27266592 |
2017 |
|
rs2239751
|
CISH;MAPKAPK3
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population, but not with HBV progression.
|
24964072 |
2014 |
|
rs414171
|
CISH;MAPKAPK3
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation |
BEFREE |
CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.
|
24791876 |
2014 |
|
rs414171
|
CISH;MAPKAPK3
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population, but not with HBV progression.
|
24964072 |
2014 |
|
rs6768300
|
CISH;MAPKAPK3
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
The other two SNPs (rs622502 and rs6768300) showed no association with persistent HBV infection.
|
24964072 |
2014 |
|
rs809451
|
CISH;MAPKAPK3
|
Tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis.
|
24632804 |
2014 |
|
rs3792323
|
MAPKAPK3
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs3792323 in MAPKAPK3 associates with the outcome of IFN therapy in patients with HCV genotype 1b.
|
19208361 |
2009 |
|
rs616589
|
MAPKAPK3
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified 2 SNPs (rs3792323 [A/T] and rs616589 [G/A]), located in intron 2 of mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3) that were associated with the outcome of IFN therapy in patients infected with hepatitis C virus (HCV) genotype 1b (P = 4.6 x 10(-5) and 4.8 x 10(-5), respectively).
|
19208361 |
2009 |