ADGB, androglobin, 79747

N. diseases: 5; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2275606
rs2275606
Entrez Id: 79747;101928661
Gene Symbol: ADGB;LOC101928661
ADGB;LOC101928661
CUI: C0023343
Disease:
Leprosy 		0.810 GeneticVariation BEFREE Previous genome-wide association study (GWAS) identified two new leprosy associated loci (1p31.3 [rs3762318] and 6q24.3 [rs2275606]). 27712858 2016
dbSNP: rs2275606
rs2275606
Entrez Id: 79747;101928661
Gene Symbol: ADGB;LOC101928661
ADGB;LOC101928661
CUI: C0023343
Disease:
Leprosy 		A 0.810 GeneticVariation GWASDB Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. 22019778 2011
dbSNP: rs2275606
rs2275606
Entrez Id: 79747;101928661
Gene Symbol: ADGB;LOC101928661
ADGB;LOC101928661
CUI: C0023343
Disease:
Leprosy 		A 0.810 GeneticVariation GWASCAT Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. 22019778 2011
dbSNP: rs73786719
rs73786719
Entrez Id: 79747
Gene Symbol: ADGB
ADGB
CUI: C0020179
Disease:
Huntington Disease 		0.700 GeneticVariation GWASCAT Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. 28642124 2017
dbSNP: rs4896888
rs4896888
Entrez Id: 79747
Gene Symbol: ADGB
ADGB
CUI: C4554344
Disease:
IgE-mediated food allergy 		0.010 GeneticVariation BEFREE Three suggestive loci with PO effect were observed: 1 for peanut allergy (rs4896888 in the ADGB gene) and 2 for any FA in boys only (rs1036504 and rs2917750 in the IQCE gene). 29489655 2018
dbSNP: rs4896888
rs4896888
Entrez Id: 79747
Gene Symbol: ADGB
ADGB
CUI: C0559470
Disease:
Allergy to peanuts 		0.010 GeneticVariation BEFREE Three suggestive loci with PO effect were observed: 1 for peanut allergy (rs4896888 in the ADGB gene) and 2 for any FA in boys only (rs1036504 and rs2917750 in the IQCE gene). 29489655 2018
dbSNP: rs2275606
rs2275606
Entrez Id: 79747;101928661
Gene Symbol: ADGB;LOC101928661
ADGB;LOC101928661
CUI: C1562585
Disease:
Leprosy, Multibacillary 		0.010 GeneticVariation BEFREE We validated the positive association of rs3762318 with multibacillary leprosy (P=7.5×10<sup>-4</sup>), whereas the association of rs2275606 could not be validated. eQTL analysis showed that both the GWAS locus rs3762318 and one surrounding positively associated SNP rs2144658 (P=1.8×10<sup>-3</sup>) significantly affected the mRNA expression of a nearby gene SLC35D1, which might be involved in metabolism. 27712858 2016