The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
Besides displaying abnormal CSF Aβ<sub>42</sub> levels, rs13333659-T carriers were more likely to exhibit a greater longitudinal cognitive decline (<i>p</i> = 0.029, <i>β</i> = 0.097) and hippocampal atrophy (<i>p</i> = 0.029, <i>β</i> = -0.160) in the non-demented elders, especially for the participants who were amyloid-positive at baseline.
Besides displaying abnormal CSF Aβ<sub>42</sub> levels, rs13333659-T carriers were more likely to exhibit a greater longitudinal cognitive decline (<i>p</i> = 0.029, <i>β</i> = 0.097) and hippocampal atrophy (<i>p</i> = 0.029, <i>β</i> = -0.160) in the non-demented elders, especially for the participants who were amyloid-positive at baseline.