DDX3Y, DEAD-box helicase 3 Y-linked, 8653

N. diseases: 25; N. variants: 1
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2032592
rs2032592
Entrez Id: 8653
Gene Symbol: DDX3Y
DDX3Y
CUI: C0011991
Disease:
Diarrhea
0.010 GeneticVariation BEFREE Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033). 21142915 2010
dbSNP: rs2032592
rs2032592
Entrez Id: 8653
Gene Symbol: DDX3Y
DDX3Y
CUI: C0027947
Disease:
Neutropenia
0.010 GeneticVariation BEFREE Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033). 21142915 2010
dbSNP: rs2032592
rs2032592
Entrez Id: 8653
Gene Symbol: DDX3Y
DDX3Y
CUI: C0852711
Disease:
Sickle Cell Dactylitis
0.010 GeneticVariation BEFREE Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033). 21142915 2010
dbSNP: rs2032592
rs2032592
Entrez Id: 8653
Gene Symbol: DDX3Y
DDX3Y
CUI: C0549410
Disease:
Palmar-plantar erythrodysesthesia syndrome
0.010 GeneticVariation BEFREE Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033). 21142915 2010
dbSNP: rs2032592
rs2032592
Entrez Id: 8653
Gene Symbol: DDX3Y
DDX3Y
CUI: C0023530
Disease:
Leukopenia
0.010 GeneticVariation BEFREE Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033). 21142915 2010