IRS2, insulin receptor substrate 2, 8660

N. diseases: 152; N. variants: 6
Disease: Breast Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2241745
rs2241745
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE This meta-analysis indicated that IRS2 rs1805097 polymorphism was not associated with colorectal and breast cancer risk. 24497996 2014
dbSNP: rs2289046
rs2289046
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE When these three SNPs were examined as a haplotype, only the haplotype that included the G allele of rs2289046 was associated with breast cancer (odds ratio = 0.76, 95% confidence interval = 0.63-0.92 for TGC versus CAT). 18611262 2008
dbSNP: rs754204
rs754204
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Three of the 11 SNPs for IRS2 were associated with breast cancer (rs4773082, P = 0.007; rs2289046, P = 0.016; rs754204, P = 0.03). 18611262 2008