|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Pancreatitis
|
|
0.710 |
GeneticVariation |
BEFREE |
Effects of PRSS1-PRSS2 rs10273639, CLDN2 rs7057398 and MORC4 rs12688220 polymorphisms on individual susceptibility to pancreatitis: A meta-analysis.
|
31163246 |
2020 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Pancreatitis, Alcoholic
|
|
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
|
28754779 |
2018 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Pancreatitis, Alcoholic
|
|
0.710 |
GeneticVariation |
BEFREE |
In a much broader approach employing genome wide search strategies the NAPS study found that polymorphisms in the Trypsin locus (PRSS1 rs10273639), and the Claudin 2 locus (CLDN2-RIPPLY1-MORC4 locus rs7057398 and rs12688220) confer an increased risk of developing alcohol-induced pancreatitis.
|
26149858 |
2015 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Pancreatitis
|
|
0.710 |
GeneticVariation |
GWASDB |
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
|
23143602 |
2012 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Acute pancreatitis
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings suggested that rs7057398, rs12688220 and rs10273639 polymorphisms could be used to identify individuals at an elevated susceptibility to acute pancreatitis in Caucasians.
|
31163246 |
2020 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Acute pancreatitis
|
|
0.020 |
GeneticVariation |
BEFREE |
Meta-analyses of all AP patients depicted significant (p-value < 0.05) associations for rs10273639 (odds ratio (OR) 0.88, 95% confidence interval (CI) 0.81-0.97, p-value 0.01), rs7057398 (OR 1.27, 95% CI 1.07-1.5, p-value 0.005), and rs12688220 (OR 1.32, 95% CI 1.12-1.56, p-value 0.001).
|
29884332 |
2018 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Pancreatitis, Chronic
|
|
0.020 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms rs10273639 at the PRSS1-PRSS2 locus and rs7057398 and rs12688220 at the CLDN2-MORC4 locus are associated with CP and strongly associate with ACP, but only rs7057398 with NACP in female patients.
|
25253127 |
2015 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Pancreatitis, Chronic
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we have demonstrated the association of claudin2 (rs7057398) polymorphism with IRAP and progression of IRAP to CP, and PRSS1 (rs10273639) polymorphism with IRAP and ICP.
|
26110235 |
2015 |
|
rs7057398
|
CLDN2;MORC4;RIPPLY1
|
Idiopathic chronic pancreatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we have demonstrated the association of claudin2 (rs7057398) polymorphism with IRAP and progression of IRAP to CP, and PRSS1 (rs10273639) polymorphism with IRAP and ICP.
|
26110235 |
2015 |