|
rs121917815
|
ADIPOQ;ADIPOQ-AS1
|
Hypoadiponectinemia
|
|
0.710 |
GeneticVariation |
BEFREE |
R112C and I164T mutants, which are associated with hypoadiponectinemia, did not assemble into trimers, resulting in impaired secretion from the cell.
|
12878598 |
2003 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggested that the ADIPOQ rs1501299 (+276G>T) polymorphism is a low-risk factor for the development of CVDs with T2D, but the association of this polymorphism with the susceptibility to CVDs in other populations remains unknown.
|
22040602 |
2012 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
|
24825737 |
2015 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A > G (rs16861194), -11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk.
|
23653335 |
2013 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.
|
31755094 |
2019 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies.
|
19631916 |
2009 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Together, our data support that the rs2241766 and rs1501299 polymorphisms within the ADIPOQ gene confer genetic susceptibility for type 2 diabetes, especially in the Chinese Han population.
|
25135112 |
2014 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
This study observed that the SNPs rs3792267 in CAPN10, rs1501299 in APM1, and rs3760776 in FUT6 might serve as potential susceptible biomarkers for T2DM in Uyghurs.
|
27374856 |
2016 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes.
|
21638131 |
2011 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM.
|
23260797 |
2013 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM.
|
31128439 |
2019 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Two individual polymorphisms (ADIPOQ rs1501299, KCNJ11 rs5219) were found to be associated with T2D.
|
30467975 |
2019 |
|
rs1501299
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Of the 8 variants, four SNPs namely, +276 G/T (rs1501299), -4522 C/T (rs822393), -11365 C/G (rs266729), and +712 G/A (rs3774261) were significantly associated with T2DM in our study population.
|
24055485 |
2013 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies will be necessary to confirm the role of SNP 276G>T and 45T>G in the development of CAD.
|
16926524 |
2006 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation |
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Obesity
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2241766/rs3774261 haplotype was also associated with obesity (nominal p = 0.004).
|
19573164 |
2009 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
|
29686595 |
2018 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective was to examine the association of two SNPs (45T/G and 276G/T) with coronary artery disease in a Tunisian population.
|
21738048 |
2011 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The two SNPs (45T-->G and 276G-->T) were chosen because of their association with type 2 diabetes in Japanese.
|
12086965 |
2002 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
|
15842511 |
2005 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our results demonstrated that, adiponectin SNP 45T/G, rather than SNP 276G/T, is more associated with risk of T2DM in obese individuals.
|
19929719 |
2009 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2241766 polymorphism is found to be associated with a significant increase in CAD risk in Caucasian and genotyping method (PCR-RFLP) subgroups.
|
28881706 |
2017 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.
|
29627525 |
2018 |
|
rs2241766
|
ADIPOQ;ADIPOQ-AS1
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the SNPs +45T>G (rs2241766), -4034A>C (rs822395), and -11391G>A (rs17300539) were linked to CAD development.
|
28617663 |
2017 |