|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
In conclusion, some variants associated with CRC risk (rs10505477, rs6983267, rs10795668 and rs11255841) are also involved in the susceptibility to CRA and specific subtypes.
|
30194776 |
2019 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
In particular, both homozygous TT and heterozygous CT genotypes of rs10505477, as well as the GG and TG genotypes of rs6983267, were associated with risk of colorectal cancer.Our study provides summary evidence that common variants in the 8q24 are associated with risk of colorectal cancer in this large-scale research synopsis and meta-analysis.
|
30170403 |
2018 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
Long non-coding RNA (lncRNA) CASC8 rs10505477 polymorphism has been identified to be related to risk of many kinds of cancers, such as colorectal cancer, gastric cancer, and invasive ovarian cancer, and it may be involved in the prognosis of gastric cancer patients who have received platinum-based chemotherapy after surgical treatment.
|
27249003 |
2016 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified the SNP rs10505477 and SNP rs1562430 in CASC8 were associated with risk of the colorectal cancer (CRC) and breast cancer, respectively.
|
25302443 |
2015 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
Furthermore, the A allele of rs7014346, the A allele of rs10505477, and the T allele of rs4939827 were significantly related with an elevated risk of CRC only among Caucasian.Our study suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for CRC among both Caucasian and Asian whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasian.
|
26579801 |
2015 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
Results of this study suggests that the rs6983267 and rs10505477 polymorphisms alone may not be relevant to CRC risk, but their GG haplotype plays a notable role in age at diagnosis of CRC in the Iranian population.
|
24528058 |
2014 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
A meta-analysis of included studies of rs10505477 polymorphisms identified allelic and genotypic associations with CRC risk in the US patients.
|
21722176 |
2011 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
Among 1,861 incident cases and 1,937 population-based controls matched on age, gender, ethnicity, and clinic, rs10505477 was associated with risk of CRC in a dominant model, with an odds ratio = 1.23, 95% confidence interval = 1.05-1.43, (p = 0.008).
|
17630503 |
2007 |
|
Colorectal Carcinoma
|
|
0.890 |
GeneticVariation
|
BEFREE |
In the population-based series, we also detected statistically significant associations between two SNPs on 8q24, rs10505477 and rs6983267, and risk of CRC (P = 0.005 and P = 0.002, respectively).
|
18056436 |
2007 |
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Long non-coding RNA (lncRNA) CASC8 rs10505477 polymorphism has been identified to be related to risk of many kinds of cancers, such as colorectal cancer, gastric cancer, and invasive ovarian cancer, and it may be involved in the prognosis of gastric cancer patients who have received platinum-based chemotherapy after surgical treatment.
|
27249003 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Long non-coding RNA (lncRNA) CASC8 rs10505477 polymorphism has been identified to be related to risk of many kinds of cancers, such as colorectal cancer, gastric cancer, and invasive ovarian cancer, and it may be involved in the prognosis of gastric cancer patients who have received platinum-based chemotherapy after surgical treatment.
|
27249003 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped the 940 surgically resected gastric cancer patients to explore the association between these two SNPs (e.g., rs10505477 and rs1562430) and survival of gastric cancer in a Chinese population.
|
25302443 |
2015 |
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped the 940 surgically resected gastric cancer patients to explore the association between these two SNPs (e.g., rs10505477 and rs1562430) and survival of gastric cancer in a Chinese population.
|
25302443 |
2015 |
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the female subgroup, the rs6983267 GT genotype (compared with TT, OR = 2.31, 95%CI = 1.07-4.99) and the rs10505477 CT genotype (compared with TT, OR = 2.36, 95%CI = 1.09-5.11) significantly increased the risk for GC.
|
24854447 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the female subgroup, the rs6983267 GT genotype (compared with TT, OR = 2.31, 95%CI = 1.07-4.99) and the rs10505477 CT genotype (compared with TT, OR = 2.36, 95%CI = 1.09-5.11) significantly increased the risk for GC.
|
24854447 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.
|
25046748 |
2014 |
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.
|
25046748 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
In particular, both homozygous TT and heterozygous CT genotypes of rs10505477, as well as the GG and TG genotypes of rs6983267, were associated with risk of colorectal cancer.Our study provides summary evidence that common variants in the 8q24 are associated with risk of colorectal cancer in this large-scale research synopsis and meta-analysis.
|
30170403 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
Long non-coding RNA (lncRNA) CASC8 rs10505477 polymorphism has been identified to be related to risk of many kinds of cancers, such as colorectal cancer, gastric cancer, and invasive ovarian cancer, and it may be involved in the prognosis of gastric cancer patients who have received platinum-based chemotherapy after surgical treatment.
|
27249003 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association of 8q24.21 rs10505477-rs6983267 haplotype and age at diagnosis of colorectal cancer.
|
24528058 |
2014 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two SNPs (rs10505477, rs6983267) in the CASC8 gene were associated with a reduced risk of CRA in controls (log-additive models, OR: 0.67, 95%CI:0.54-0.83, and OR:0.66, 95%CI:0.54-0.84, respectively).
|
30194776 |
2019 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two of these SNPs, rs10505477 and rs719725, showed evidence of an association in both CRC and CRA in our study population.
|
27769063 |
2016 |
|
Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratified analysis by histological lesion revealed the association of rs10505477 and rs6983267 variants with reduced risk of low- and high-risk adenomas in controls, being this effect stronger in low-risk adenomas (log-additive models, OR:0.63, 95%CI:0.47-0.84 and OR:0.64, 95%CI:0.47-0.86, respectively).
|
30194776 |
2019 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10505477 and rs7837328 polymorphisms might be associated with risk of cancer.
|
30214306 |
2018 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10505477 and rs7837328 polymorphisms might be associated with risk of cancer.
|
30214306 |
2018 |