Glioblastoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Histopathologically, the four G34R-mutant cases included three glioblastomas and one astroblastoma.
|
28447171 |
2017 |
Glioblastoma
|
|
0.740 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Glioblastoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V).
|
23414300 |
2013 |
Glioblastoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
Glioblastoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Exon sequencing has identified a mutation in K27M of the histone H3.3 gene (H3F3A K27M and G34R/V) in about 20% of pediatric glioblastomas, but it remains to be seen whether these mutations can be considered specific for pediatric diffuse high-grade astrocytomas or also occur in other pediatric brain tumors.
|
23429371 |
2013 |
Adrenocortical carcinoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Brain Neoplasms
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Brain Stem Glioma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that G34R-mutant tumors are likely to show extensive infiltration and alterations in global histone trimethylation might also play an important role in G34R mutant tumors.
|
28447171 |
2017 |
Glioblastoma Multiforme
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
Glioblastoma Multiforme
|
|
0.020 |
GeneticVariation
|
BEFREE |
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V).
|
23414300 |
2013 |
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Mutations in ATRX (α-thalassaemia/mental retardation syndrome X-linked) and DAXX (death-domain associated protein), encoding two subunits of a chromatin remodelling complex required for H3.3 incorporation at pericentric heterochromatin and telomeres, were identified in 31% of samples overall, and in 100% of tumours harbouring a G34R or G34V H3.3 mutation.
|
22286061 |
2012 |
High grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Extraneural Metastases From a High-Grade Glioma (HGG) With an H3F3A G34R Mutation.
|
31139567 |
2019 |
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report the case of a 17-year-old female with an H3F3A G34R mutated infiltrative glioma who developed painful osseous metastases to her pelvis and spine within 3 months of clinical presentation.
|
31139567 |
2019 |
Malignant Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Extraneural Metastases From a High-Grade Glioma (HGG) With an H3F3A G34R Mutation.
|
31139567 |
2019 |
Neoplasms, Neuroepithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components.
|
31109382 |
2019 |
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report the case of a 17-year-old female with an H3F3A G34R mutated infiltrative glioma who developed painful osseous metastases to her pelvis and spine within 3 months of clinical presentation.
|
31139567 |
2019 |
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report the case of a 17-year-old female with an H3F3A G34R mutated infiltrative glioma who developed painful osseous metastases to her pelvis and spine within 3 months of clinical presentation.
|
31139567 |
2019 |
Giant Cell Tumor of Bone
|
|
0.010 |
GeneticVariation
|
BEFREE |
Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR).
|
29254795 |
2018 |
Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Notably an additional 2 previously reported osteosarcomas with a p.G34R mutation were not immunoreactive for the antibody.
|
28505000 |
2017 |
Astroblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Histopathologically, the four G34R-mutant cases included three glioblastomas and one astroblastoma.
|
28447171 |
2017 |
Microvascular Angina
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mutations in ATRX (α-thalassaemia/mental retardation syndrome X-linked) and DAXX (death-domain associated protein), encoding two subunits of a chromatin remodelling complex required for H3.3 incorporation at pericentric heterochromatin and telomeres, were identified in 31% of samples overall, and in 100% of tumours harbouring a G34R or G34V H3.3 mutation.
|
22286061 |
2012 |