|
Squamous cell carcinoma of the head and neck
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Brain Stem Glioma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
GLIOMA SUSCEPTIBILITY 1
|
|
0.700 |
GeneticVariation
|
UNIPROT |
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
|
22286216 |
2012 |
|
Diffuse Intrinsic Pontine Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, our study demonstrates a high frequency of histone K27M mutations in DIPG when MRI features are carefully assessed, thus confirming the consistency of imaging with biological markers in our institutional series of DIPG.
|
31848724 |
2020 |
|
Diffuse Intrinsic Pontine Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs.
|
26727948 |
2016 |
|
Diffuse Intrinsic Pontine Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
All DIPG</span> but one were found to harbour either a somatic H3-K27M mutation and/or loss of H3K27 trimethylation.
|
26399631 |
2015 |
|
Diffuse Intrinsic Pontine Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Sequencing analysis showed c.83A>T mutations in the H3F3A or HIST1H3B gene in 77 % of our DIPG cohort.
|
24297113 |
2014 |
|
Diffuse Intrinsic Pontine Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein.
|
22286216 |
2012 |
|
Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Mutated IDH1 R132H protein and H3F3A K27M mutations indicate that a substantial number of GBMc are "metastatic" or "diaschismatic" lesions.
|
30203362 |
2018 |
|
Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
|
Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
K27M- and G34V-H3.3 have location-based incidence (brainstem/cortex) and potentially play distinct roles in pediatric GBM pathogenesis.
|
22661320 |
2012 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found 56 H3.3 K27M</span>-mutant tumors (66%), 6 H3.1 K27M-mutant tumors (7%), and 23 H3-wildtype tumors (27%).
|
29016894 |
2018 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Patients with tumours harbouring a K27M mutation in H3.3 (H3F3A) did not respond clinically to radiotherapy as well, relapsed significantly earlier and exhibited more metastatic recurrences than those in H3.1 (HIST1H3B/C).
|
26399631 |
2015 |
|
gliosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We histopathologically identified 14 glioblastomas, 4 grade III astrocytomas and 1 gliosarcoma.Two cases showed a H3F3A K27M mutation.
|
29809131 |
2019 |
|
Adult Gliosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We histopathologically identified 14 glioblastomas, 4 grade III astrocytomas and 1 gliosarcoma.Two cases showed a H3F3A K27M mutation.
|
29809131 |
2019 |
|
Brain Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive pediatric brain tumors that are characterized by a recurrent mutation (K27M) within the histone H3 encoding genes H3F3A or HIST1H3A/B/C.
|
30943283 |
2019 |
|
Childhood Gliosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We histopathologically identified 14 glioblastomas, 4 grade III astrocytomas and 1 gliosarcoma.Two cases showed a H3F3A K27M mutation.
|
29809131 |
2019 |
|
Cerebellar Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
|
29264735 |
2018 |
|
High Grade Astrocytic Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
We herein present the case of an adult cerebellar high-grade astrocytic tumor with H3.1 K27M mutation in a 45-year-old man, which also involvedTP53 mutation and was immunonegative for ATRX.
|
29264735 |
2018 |
|
Malignant Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
|
29264735 |
2018 |
|
High grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
|
29264735 |
2018 |
|
Monosomy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this series, histone H3-K27M mutation was mutually exclusive with IDH1 mutation and EGFR amplification, rarely co-occurred with BRAF-V600E mutation, and was commonly associated with p53 overexpression, ATRX loss (except in pontine gliomas), and monosomy 10.
|
26517431 |
2016 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs.
|
26727948 |
2016 |
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |