|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The data suggest that there may be a weak association with T1D for two OAS1 polymorphisms, rs3741981 and rs10774671, in populations of European descent.
|
19956105 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, it was reported that an A/G splice-site single nucleotide polymorphism (SNP; rs10774671) in the OAS1 gene, encoding 2'5'-oligoadenylate synthetase, was associated with a protective effect against type 1 diabetes in unaffected siblings, and yet affected siblings showed random transmission.
|
16644715 |
2006 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
We confirm the T1D association with rs10774671, but we conclude that it cannot be attributed (solely) to the splicing variant rs10774671.
|
16014697 |
2006 |
|
Sjogren's Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SS risk allele of rs10774671 has been shown by others to be associated with reduced OAS1 enzymatic activity and ability to clear viral infections, as well as reduced responsiveness to IFN treatment.
|
28640813 |
2017 |
|
Sjogren's Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS.
|
29242559 |
2017 |
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.
|
26505957 |
2015 |
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, individuals carrying the A allele in these SNPs exhibited an increased risk for chronic HCV infection (rs2660 and rs10774671</span>: OR = 1.356 [1.051-1.749]; rs3741981: 1.363 [1.085-1.712]).
|
22710942 |
2013 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the initial study, the G allele of rs10774671</span> was a </span>significantly protective factor against TB (P = 0.006) and the genotype of GG differed significantly between TB patients and controls under the codominant model (P = 0.008) after Bonferroni correction.
|
30497421 |
2018 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS.
|
29242559 |
2017 |
|
Virus Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SS risk allele of rs10774671 has been shown by others to be associated with reduced OAS1 enzymatic activity and ability to clear viral infections, as well as reduced responsiveness to IFN treatment.
|
28640813 |
2017 |
|
Coinfection
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we examined the association between single-nucleotide polymorphisms (SNPs) in 3 innate immunity genes [2'-5'oligoadenylate synthetase 1 (OAS1) rs10774671, interleukin 28B (IL28B) rs12979860, and low molecular mass polypeptide 7 (LMP-7) at codon 49] besides cytomegalovirus (CMV) coinfection and susceptibility to HCC in genotype 4 (GT4) chronically infected Egyptian patients.
|
27726464 |
2016 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, OAS1 rs10774671 does not seem to contribute to the development of HCC.
|
27726464 |
2016 |
|
Chikungunya Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in the promoter region of CD209 gene (rs735239, rs4804803, rs2287886) and OAS1 (rs1131454 and rs10774671), OAS2 (rs15895 and rs1732778), and OAS3 (rs2285932 and rs2072136) genes were investigated in 100 patients with CHIKV infection and 101 healthy controls to find out the association of these polymorphisms with CHIKV infection.
|
26398832 |
2016 |
|
Fibrosis, Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.
|
26505957 |
2015 |
|
Hand, Foot and Mouth Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In short, the OAS1 rs10774671 SNP GG genotype contributed to CA16 susceptibility and was associated with the development of mild HFMD.
|
25059424 |
2014 |
|
Dengue Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in the OAS1 (rs1131454 and rs10774671), OAS3 (rs2285932 and rs2072136) and OAS2 (rs15895 and rs1732778) genes were studied using PCR followed by restriction fragment length polymorphism methods in 109 patients hospitalized for dengue (DEN) and 105 healthy controls (HCs) who have no documented evidence of symptomatic dengue.
|
23337612 |
2013 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association was found between rs10774671 and MS. As the two SNPs are in linkage disequilibrium in Europeans, the previously reported association between rs10774671 and MS susceptibility might be driven by rs11352835, possibly explaining the contrasting results previously observed for the splice-site polymorphism.
|
21735172 |
2012 |
|
West Nile viral infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans.
|
19247438 |
2009 |