|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
Additionally, our GWAS confirmed the previously reported association with CRC of five SNPs located at 3q36.2 (rs10936599), 8q24 (rs10505477), 8q24.21(rs6983267), 11q13.4 (rs3824999) and 14q22.2 (rs4444235).
|
24978480 |
2014 |
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls.
|
22999960 |
2013 |
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
It was independently found that the same rs10936599 allele was associated with increased risk of both CRC and colorectal adenomas.
|
21708826 |
2012 |
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 × 10⁻¹⁰ and rs6687758, OR = 1.09, P = 2.27 × 10⁻⁹, 3q26.2 (rs10936599, OR = 0.93, P = 3.39 × 10⁻⁸), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 × 10⁻¹⁰ and rs7136702, OR = 1.06, P = 4.02 × 10⁻⁸) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 × 10⁻¹⁰).
|
20972440 |
2010 |
|
Multiple Myeloma
|
|
0.810 |
GeneticVariation
|
BEFREE |
Common single-nucleotide polymorphisms (SNPs) at 2p23.3 (rs6746082), 3p22.1 (rs1052501), 3q26.2 (rs10936599), 6p21.33 (rs2285803), 7p15.3 (rs4487645), 17p11.2 (rs4273077), and 22q13.1 (rs877529) have recently been shown to influence MM risk.
|
24449210 |
2014 |
|
Carcinoma of bladder
|
|
0.720 |
GeneticVariation
|
BEFREE |
At the end of the study, we suggested that there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population.
|
30120764 |
2019 |
|
Malignant neoplasm of urinary bladder
|
|
0.720 |
GeneticVariation
|
BEFREE |
At the end of the study, we suggested that there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population.
|
30120764 |
2019 |
|
Carcinoma of bladder
|
|
0.720 |
GeneticVariation
|
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
|
Malignant neoplasm of urinary bladder
|
|
0.720 |
GeneticVariation
|
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
At the end of the study, we suggested that there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population.
|
30120764 |
2019 |
|
Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R<sup>2</sup>>0.5) with GWAS-identified RCC risk variants (rs10936599 and rs9420907) from the telomere length GRS; despite this exclusion, a statistically significant association between the GRS and RCC risk persisted (OR=1.73, 95% CI=1.36-2.21, p<0.0001).
|
28797570 |
2017 |
|
Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Rs35073794, rs10936599 and rs10069690 were positively correlated with the age older than 55 (OR= 3.27, 95%CI= 1.08-9.93, <i>p</i>=0.031; OR= 1.56, 95%CI= 1.03-2.37, <i>p=</i> 0.034; OR= 4.94, 95%CI= 1.18-20.70, <i>p=</i> 0.022, respectively) with or without history of drinking(OR= 4.47, 95%CI= 0.99-20.25, <i>p=</i> 0.024<i>;</i> OR= 2.62, 95%CI= 1.13-6.08, <i>p=</i> 0.022<i>;</i> OR=2.44, 95%CI=1.03-5.78, <i>p</i>= 0.04, respectively) and clinical stage I/II RCC (OR=2.62, 95%CI=1.02-6.74, <i>p</i>= 0.045; OR= 2.23, 95%CI= 1.08-4.60, <i>p=</i> 0.028; OR= 1.63, 95%CI= 1.17-2.27, <i>p</i>= 0.014, respectively).
|
29100352 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R<sup>2</sup>>0.5) with GWAS-identified RCC risk variants (rs10936599 and rs9420907) from the telomere length GRS; despite this exclusion, a statistically significant association between the GRS and RCC risk persisted (OR=1.73, 95% CI=1.36-2.21, p<0.0001).
|
28797570 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Rs35073794, rs10936599 and rs10069690 were positively correlated with the age older than 55 (OR= 3.27, 95%CI= 1.08-9.93, <i>p</i>=0.031; OR= 1.56, 95%CI= 1.03-2.37, <i>p=</i> 0.034; OR= 4.94, 95%CI= 1.18-20.70, <i>p=</i> 0.022, respectively) with or without history of drinking(OR= 4.47, 95%CI= 0.99-20.25, <i>p=</i> 0.024<i>;</i> OR= 2.62, 95%CI= 1.13-6.08, <i>p=</i> 0.022<i>;</i> OR=2.44, 95%CI=1.03-5.78, <i>p</i>= 0.04, respectively) and clinical stage I/II RCC (OR=2.62, 95%CI=1.02-6.74, <i>p</i>= 0.045; OR= 2.23, 95%CI= 1.08-4.60, <i>p=</i> 0.028; OR= 1.63, 95%CI= 1.17-2.27, <i>p</i>= 0.014, respectively).
|
29100352 |
2017 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
|
Adult Meningioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether six genetic variants previously associated with LTL (TERC (rs10936599), TERT (rs2736100), NAF1 (7675998), OBFC1 (rs9420907), ZNF208 (rs8105767), and RTEL1 (rs755017)) are correlated with telomere length (TL) in peripheral blood mononuclear cells (PBMCs) in a cohort of Africans living with and without HIV and undergoing evaluation for tuberculosis (TB).
|
31388112 |
2019 |
|
Meningioma, benign, no ICD-O subtype
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
Meningioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 10 SNPs (ZNF676-rs409627, TERT-rs2736100, CTC1-rs3027234, DHX35-rs6028466, PXK-rs6772228, NAF1-rs7675998, ZNF208-rs8105767, OBFC1-rs9420907, ACYP2-rs11125529 and TERC-rs10936599) alone and combined in a LTL genetic score ("teloscore", which explains 2.2% of the telomere variability) in relation to PDAC risk in 2,374 cases and 4,326 controls.
|
30325019 |
2019 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study indicated that rs10936599 (<i>TERC</i>) and rs10069690, rs2242652 and rs2853677 in <i>TERT</i> and haplotype "TA" of <i>TERT</i> were revealed as risk factors of lung cancer in a Chinese Han population.
|
29299136 |
2017 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
In allele association analysis, allele "C" in rs10936599 of TERC gene and allele "G" in rs2853677 of TERT gene were found to have an increased risk of IS when compared with allele "T" and "A", respectively.
|
28057933 |
2017 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study indicated that rs10936599 (<i>TERC</i>) and rs10069690, rs2242652 and rs2853677 in <i>TERT</i> and haplotype "TA" of <i>TERT</i> were revealed as risk factors of lung cancer in a Chinese Han population.
|
29299136 |
2017 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study indicated that rs10936599 (<i>TERC</i>) and rs10069690, rs2242652 and rs2853677 in <i>TERT</i> and haplotype "TA" of <i>TERT</i> were revealed as risk factors of lung cancer in a Chinese Han population.
|
29299136 |
2017 |
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic predisposition to advanced biological ageing, as assayed using rs10936599, predicted a small, but significant, increased risk for childhood-onset recurrent MDD.
|
28233563 |
2017 |