|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
Significant heterogeneity was observed in Caucasian population in subgroup analysis of the association studies of rs11206510 with CHD (P=0.003, I(2)=67.2%).
|
23380588 |
2013 |
|
Myocardial Infarction
|
|
0.810 |
GeneticVariation
|
BEFREE |
Two-sided <i>P</i> values <0.05 were considered significant.<b>Results:</b> We observed a significant interaction between the <i>PCSK9</i> rs11206510 genotype and LC n-3 PUFA intake on nonfatal MI risk (<i>P</i>-interaction = 0.012).
|
28330911 |
2017 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|
23100282 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Our results indicate that single nucleotide polymorphism rs11206510 is associated with LDL-C levels and early-onset CAD in the Chinese Han population.
|
20576952 |
2010 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Eight SNPs (rs11206510, rs10118757, rs2383206, rs501120, rs2075292, rs174547, rs173539, and rs255052) were nominally significantly associated with CAD (P<0.05), and 5 of them were newly reported.
|
22664640 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|
23100282 |
2013 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Squamous cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, the LDL-C-lowering allele of rs11206510 in PCSK9 was weakly associated with a lower AAA risk (OR, 0.94; 95% CI, 0.88-1.00; P = .04), but a second independent LDL-C-lowering variant in PCSK9 (rs2479409) was not associated with AAA risk (OR, 0.97; 95% CI, 0.92-1.02; P = .28).
|
29188294 |
2018 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the first time to our knowledge, this study also demonstrates that rs11206510 confers a significant risk of ischemic stroke.
|
20576952 |
2010 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, we hypothesized that certain <i>PCSK9</i> genetic variants may modify the association between LC n-3 PUFA intake and CVD risk.<b>Objective:</b> We determined whether a <i>PCSK9</i> variant (rs11206510), which has been identified for early onset myocardial infarction (MI), modified the association of LC n-3 PUFAs with nonfatal MI risk in Costa Rican Hispanics.<b>Design:</b> We analyzed cross-sectional data from 1932 case subjects with a first nonfatal MI and 2055 population-based control subjects who were living in Costa Rica to examine potential gene-environment interactions.
|
28330911 |
2017 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of this study was to evaluate the PCSK9 polymorphisms rs505151 (c.2009A>G), rs562556 (c.1420A>G) and rs11206510 (T>C) and plasma PCSK9 levels in PCOS.
|
29109005 |
2018 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although PCSK9 r</span>s11206510 was not associated with hypertension</span>, our study confirms its association with serum cholesterol levels.
|
26266351 |
2015 |