|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
Significant heterogeneity was observed in Caucasian population in subgroup analysis of the association studies of rs11206510 with CHD (P=0.003, I(2)=67.2%).
|
23380588 |
2013 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Myocardial Infarction
|
|
0.810 |
GeneticVariation
|
BEFREE |
Two-sided <i>P</i> values <0.05 were considered significant.<b>Results:</b> We observed a significant interaction between the <i>PCSK9</i> rs11206510 genotype and LC n-3 PUFA intake on nonfatal MI risk (<i>P</i>-interaction = 0.012).
|
28330911 |
2017 |
|
Myocardial Infarction
|
|
0.810 |
GeneticVariation
|
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Myocardial Infarction
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
|
Myocardial Infarction
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|
23100282 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
|
20864672 |
2010 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
|
20864672 |
2010 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
19060906 |
2009 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
19060906 |
2009 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Eight SNPs (rs11206510, rs10118757, rs2383206, rs501120, rs2075292, rs174547, rs173539, and rs255052) were nominally significantly associated with CAD (P<0.05), and 5 of them were newly reported.
|
22664640 |
2012 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Our results indicate that single nucleotide polymorphism rs11206510 is associated with LDL-C levels and early-onset CAD in the Chinese Han population.
|
20576952 |
2010 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|
23100282 |
2013 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |