|
Crohn Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
We analysed 263 patients with psoriasis, 199 patients with Crohn's disease (CD), 282 patients with ulcerative colitis (UC), and 253 controls for rs1884444, rs11805303, rs7517847, rs2201841, rs10889677 and rs11209032 variants.
|
23093364 |
2013 |
|
Crohn Disease
|
|
0.710 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Only a systematic review was conducted for rs12119179, rs11209032, and rs12141431, owing to the lack of sufficient data.<b>Conclusion</b>: This meta-analysis indicated that rs17375018 (G/A) and rs924080 (T/C) were associated with BD susceptibility.
|
31814470 |
2019 |
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, the rs924080 association was absent after conditioning on the primary association with rs11209032, which, in contrast, was robust to conditioning on all other AS-associated SNPs in this region (P<2 × 10<sup>-8</sup>).
|
28381868 |
2017 |
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
SNPs (rs924080 and rs11209032) of the IL23R-IL12RB2 region were found to be associated with BD in a Northern Chinese Han population.
|
27660093 |
2016 |
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies of rs17375018, rs7517847, and rs11209032 were not different between the patients with AS and the healthy controls.
|
23840727 |
2013 |
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Meta-analysis revealed a significant association between AS and the two alleles of rs11209032 polymorphism in all study subjects (OR = 1.182, 95% CI 1.120-1.249, P = 0.000).
|
22089529 |
2012 |
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results also suggested that both rs11209032 AA and rs17375018 GG of IL-23R are predisposing genotypes for BD and that the AGCG haplotype may provide protection against BD.
|
20375120 |
2010 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups.
|
27902482 |
2017 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis supports that two polymorphisms (rs11209026 and rs7517847) in the IL-23 gene may be considered to be protective factors against developing UC among Caucasian populations; while the rs11209032 polymorphisms may increase the risk of UC among Caucasian populations; furthermore, the rs1088967 polymorphisms in the IL-23 gene may be considered to be protective factors against developing UC among Asian populations.
|
25497273 |
2015 |
|
Aplastic Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Current study results support that functional STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) variants may associate with occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China.
|
29330562 |
2018 |
|
Uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, homozygote models, including the rs17375018 GG genotype and rs11209032 AA genotype, were significantly associated with uveitis</span>.
|
28558665 |
2017 |
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate the possible association of IL-23R gene single-nucleotide polymorphisms (SNPs) with ITP and the association with the clinical outcome of pulsed high-dose dexamethasone (HD-DXM) therapy, four SNPs in the IL-23R gene, rs10889677, rs1884444, rs7517847, and rs11209032, were tested in a cohort of 75 ITP subjects and 81 controls by direct sequencing.
|
23564312 |
2013 |
|
Fuchs' syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggested that the rs11209032 AA genotype of the IL23R gene may predispose for Fuchs' syndrome in Chinese patients.
|
21151597 |
2010 |
|
Sjogren's Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In our study, we genotyped groups of patients with AS (n = 206), SS (n = 156) and healthy controls (n = 235) for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, rs11209026, rs10489629, rs7517847 and rs7530511 variants using PCR-RFLP methods.
|
19522770 |
2009 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the UK case-control study with new cases, four of the eight SNPs showed significant associations, whereas in the extended UK study, seven of the eight IL-23R SNPs showed significant associations (P < 0.05) with AS, maximal with rs11209032 (P < 10(-5), OR 1.3), when cases with IBD and/or psoriasis were excluded.
|
19189980 |
2009 |