rs1143643, IL1B

N. diseases: 10
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Human papilloma virus infection
CUI: C0343641
Disease: Human papilloma virus infection
0.010 GeneticVariation BEFREE IL1B rs1143643 was associated with protection against HPV infection in case/control analysis. 26945813 2016
Stress, Psychological
CUI: C0038443
Disease: Stress, Psychological
0.010 GeneticVariation BEFREE We found that rs16944 minor (A) allele specifically interacted with childhood adversity increasing depressive and anxiety symptoms, while rs1143643's minor (A) allele showed protective effect against depressive symptoms after recent life stress. 26891860 2016
Anxiety symptoms
CUI: C0860603
Disease: Anxiety symptoms
0.010 GeneticVariation BEFREE Therefore we examined the effects of rs16944 and rs1143643 single nucleotide polymorphisms (SNPs) within the IL1B gene on depressive and anxiety symptoms, as measured by the Brief Symptom Inventory, in a Hungarian population sample of 1053 persons. 26891860 2016
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.010 GeneticVariation BEFREE We found that rs16944 minor (A) allele specifically interacted with childhood adversity increasing depressive and anxiety symptoms, while rs1143643's minor (A) allele showed protective effect against depressive symptoms after recent life stress. 26891860 2016
Deep caries
CUI: C0333523
Disease: Deep caries
0.010 GeneticVariation BEFREE A single-nucleotide polymorphism in IL1B (rs1143643) showed allelic (P = .02) and genotypic (P = .004) association with cases of deep caries and periapical lesions. 25476976 2015
Sepsis
CUI: C0243026
Disease: Sepsis
0.010 GeneticVariation BEFREE Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). 25000179 2014
Septicemia
CUI: C0036690
Disease: Septicemia
0.010 GeneticVariation BEFREE Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). 25000179 2014
Secondary malignant neoplasm of lymph node
0.010 GeneticVariation BEFREE In clinicopathologic features, 3 SNPs (rs1143630, rs1143633, and rs1143643) showed a strong relationship with lymph node metastasis of PTC. 23215728 2012
Papillary thyroid carcinoma
CUI: C0238463
Disease: Papillary thyroid carcinoma
0.010 GeneticVariation BEFREE In clinicopathologic features, 3 SNPs (rs1143630, rs1143633, and rs1143643) showed a strong relationship with lymph node metastasis of PTC. 23215728 2012
Thyroid associated opthalmopathies
CUI: C0339143
Disease: Thyroid associated opthalmopathies
0.010 GeneticVariation BEFREE The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). 20671275 2010