Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA.
|
28115489 |
2017 |
Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals.
|
24286297 |
2013 |
Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
The CAD-associated locus 7q32.2 is unusual in that the lead variant, rs11556924, is not in strong linkage disequilibrium with any other variant and introduces a coding change in ZC3HC1, which encodes NIPA.
|
27226629 |
2016 |
Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
Coronary heart disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA.
|
28115489 |
2017 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA.
|
24286297 |
2013 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA.
|
24286297 |
2013 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The resulting amino acid change Arg363His is associated with increased expression and nuclear mobility, as well as lower rates of cell growth in HeLa cells, further supporting a role for cell proliferation in atherosclerosis and its clinical consequences.
|
28115489 |
2017 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The resulting amino acid change Arg363His is associated with increased expression and nuclear mobility, as well as lower rates of cell growth in HeLa cells, further supporting a role for cell proliferation in atherosclerosis and its clinical consequences.
|
28115489 |
2017 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA.
|
28115489 |
2017 |
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding ZC3HC1 rs11556924, our study further supports the observed association of rs11556924 with LA IS coming from previous GWASs.
|
31679296 |
2019 |
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A subpopulation that had available follow-up data from ages of 40, 45, and 50 years was also analyzed.ZC3HC1 rs11556924 (C > T) genotype CC was associated with hypertension compared with the T-allele carriers (P = 0.013).
|
26266351 |
2015 |
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
Its major TT-genotype was associated with higher total cholesterol (P = 0.044) and LDL (P = 0.029) compared with the C-allele.We report for the first time that ZC3HC1 rs11556924 was associated with essential hypertension in 50-year-old patients.
|
26266351 |
2015 |
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA.
|
24286297 |
2013 |
Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
Coronary Artery Disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Coronary heart disease
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
Coronary heart disease
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
|
27618452 |
2016 |
Age at menarche
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Body Height
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Myocardial Infarction
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |