rs11556924, ZC3HC1

N. diseases: 21
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Age at menarche
CUI: C1314691
Disease: Age at menarche
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.030 GeneticVariation BEFREE Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA. 24286297 2013
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.030 GeneticVariation BEFREE The resulting amino acid change Arg363His is associated with increased expression and nuclear mobility, as well as lower rates of cell growth in HeLa cells, further supporting a role for cell proliferation in atherosclerosis and its clinical consequences. 28115489 2017
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.030 GeneticVariation BEFREE In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population. 31679296 2019
Atherosclerosis
CUI: C0004153
Disease: Atherosclerosis
0.030 GeneticVariation BEFREE Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA. 24286297 2013
Atherosclerosis
CUI: C0004153
Disease: Atherosclerosis
0.030 GeneticVariation BEFREE In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population. 31679296 2019
Atherosclerosis
CUI: C0004153
Disease: Atherosclerosis
0.030 GeneticVariation BEFREE The resulting amino acid change Arg363His is associated with increased expression and nuclear mobility, as well as lower rates of cell growth in HeLa cells, further supporting a role for cell proliferation in atherosclerosis and its clinical consequences. 28115489 2017
Blood basophil count (lab test)
CUI: C0200641
Disease: Blood basophil count (lab test)
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Body Height
CUI: C0005890
Disease: Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Cerebrovascular accident
CUI: C0038454
Disease: Cerebrovascular accident
0.700 GeneticVariation GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.010 GeneticVariation BEFREE These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA. 28115489 2017
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation GWASCAT A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. 26343387 2015
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation GWASCAT Association analyses based on false discovery rate implicate new loci for coronary artery disease. 28714975 2017
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation BEFREE These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA. 28115489 2017
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation BEFREE A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. 24286297 2013
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation BEFREE The CAD-associated locus 7q32.2 is unusual in that the lead variant, rs11556924, is not in strong linkage disequilibrium with any other variant and introduces a coding change in ZC3HC1, which encodes NIPA. 27226629 2016
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation BEFREE In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population. 31679296 2019
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.840 GeneticVariation GWASDB Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1
0.700 GeneticVariation GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125 2013
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation GWASCAT Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. 21378990 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation GWASDB Large-scale gene-centric analysis identifies novel variants for coronary artery disease. 21966275 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation GWASDB A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. 22319020 2012