|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
The type 2 diabetes risk rs11708067</span>-A allele showed fewer H3K27ac ChIP-seq reads in human islets, lower transcriptional activity in reporter assays in rodent β-cells (rat 832/13 and mouse MIN6), and increased nuclear protein binding compared with the rs11708067-G allele.
|
28684635 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
However, altered ADCY5 expression in AT does not seem to be the mechanism underlying the association between rs11708067 and increased T2D risk.
|
25793868 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASDB |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
In addition to previously reported type 2 diabetes risk variants in TCF7L2 and SLC30A8, SNPs in ADCY5 (rs11708067) and GLIS3 (rs7034200) displayed evidence for association with type 2 diabetes, with odds ratios of 1.23 (95% CI: 1.09, 1.39; p = 9.1×10(-4)) and 1.16 (95% CI: 1.05, 1.29; p = 3.49×10(-3)) respectively.
|
21949744 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
Birthweight was inversely associated with the type 2 diabetes risk alleles of ADCY5 rs11708067 (beta = -33 g [95% CI -55, -10], p = 0.004) and CDKAL1 rs7756992 (beta = -22 g [95% CI -43, -1], p = 0.04).
|
20490451 |
2010 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.
|
31021400 |
2019 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
|
25631608 |
2015 |
|
Body mass index
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
Body mass index
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
20081858 |
2010 |
|
Birth Weight
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
|
31043758 |
2019 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Exome-wide association study of plasma lipids in >300,000 individuals.
|
29083408 |
2017 |
|
Fasting blood sugar result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Gestational Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Notably, T2D risk alleles of the variant rs1552224 near CENTD2, rs11708067 in ADCY5 and rs11605924 in CRY2 genes associated with protection from GDM regardless of criteria applied (p < 0.025).
|
30089489 |
2018 |
|
Gestational Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30).
|
23761423 |
2013 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two variants presented a tendency to be protector factors against MetS risk: rs5945326 in DUSP9 gene (OR=0.32; 95% CI=0.17-0.62; =0.001) and rs11708067 in ADCY5 gene (OR=0.51; 95% CI=0.28-0.95; P=0.034).
|
28919193 |
2017 |
|
Impaired insulin secretion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together, these data suggest that rs11708067-A risk allele contributes to type 2 diabetes by disrupting an islet enhancer, which results in reduced <i>ADCY5</i> expression and impaired insulin secretion.
|
28684635 |
2017 |