|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
These findings indicate that rs12425791 G>A polymorphism may be a low-penetrance susceptibility marker of stroke in Asian populations and further studies are warranted to verify this association.
|
26312640 |
2016 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study (GWAS) identified two common polymorphisms (rs12425791 and rs11833579) on chromosome 12p13 that confer risk to stroke, particularly for large artery atherosclerotic (LAA) stroke.
|
26687183 |
2016 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
These results suggested that the rs12425791 and rs11833579 polymorphisms on Chromosome 12p13 may be associated with the risk of LAA stroke and might be used as candidate biomarkers for LAA stroke susceptibility.
|
26145198 |
2015 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
rs12425791 and rs11833579 were not associated with age of stroke onset (P = 0.786 and 0.340, respectively).
|
24995625 |
2014 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan.
|
22212150 |
2012 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies (GWAS) have identified two key SNPs (rs11833579 and rs12425791) on chromosome 12p13 that were significantly associated with stroke in Caucasians.
|
22938733 |
2012 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk.
|
22795341 |
2012 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians.
|
21376321 |
2011 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population.
|
20448654 |
2010 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genomewide association studies of stroke.
|
19369658 |
2009 |
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genomewide association studies of stroke.
|
19369658 |
2009 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
NINJ2 gene rs12425791 confers a susceptible factor for IS, while there is no association between NINJ2 gene rs11833579 and IS.
|
31258083 |
2019 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
New evidence from this case-control study and meta-analysis indicates that 12</span>p13 rs12425791</span>/rs1183</span>3579 polymorphisms are associated with ischemic stroke susceptibility in Asian populations.
|
31679297 |
2019 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our aim of this study was to investigate the association of the rs12425791, rs11833579 and rs12904 in the binding site of miR-200c with the risk of IS.
|
31077198 |
2019 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings indicated that rs12425791 and rs11833579 on chromosome 12p13 may be useful biomarkers for predicting the prognosis of patients with the LAA subtype of ischaemic stroke.
|
24995625 |
2014 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in Chinese populations.
|
23270316 |
2013 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent genomewide association studies have revealed an association between two single nucleotide polymorphisms, rs11833579 and rs12425791, and ischemic stroke.
|
22011019 |
2012 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, our meta-analysis suggests that rs12425791 is significantly associated with ischemic stroke in East Asian population but not Chinese Han population, of which A alleles increase the risk of ischemic stroke, whereas no evidence of association was found for rs11833579 in East Asian population as well as Chinese Han population.
|
22297388 |
2012 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggest that rs12425791 is relative to ischemic stroke risk under dominant model in Asian population, but not for rs11833579.
|
22795341 |
2012 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan.
|
22212150 |
2012 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
the single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population.
|
21148441 |
2011 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
|
21376321 |
2011 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the association between rs12425791 and IS was insignificant in Chinese Han population.
|
21832970 |
2011 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a genome-wide association study reported an association between two single nucleotide polymorphisms (SNPs) rs11833579 and rs12425791 near NINJ2 gene and ischemic stroke in Caucasians.
|
21722921 |
2011 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Direct genotyping showed that rs12425791 was associated with an increased risk of total (i.e., all types) and ischemic stroke, with hazard ratios of 1.30 (95% confidence interval [CI], 1.19 to 1.42) and 1.33 (95% CI, 1.21 to 1.47), respectively, yielding population attributable risks of 11% and 12% in the discovery cohorts.
|
19369658 |
2009 |