|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
By use of the transmission disequilibrium test (TDT), we analyzed the P187S polymorphism for association to type 1 diabetes in a population-based sample of 247 Danish nuclear type 1 diabetic families.
|
10447260 |
1999 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
Adenocarcinoma of lung (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk in a case-control study of 198 patients and 152 control subjects.
|
12163326 |
2002 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated the genetic association between a functional polymorphism (Pro 187Ser) in the human NQO1 gene and schizophrenia (244 Japanese schizophrenic patients and 204 healthy controls).
|
12834817 |
2003 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined the relationship between functionally significant polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and asthma risk in children with high lifetime exposure to ozone.
|
12969868 |
2003 |
|
Alcohol withdrawal syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, GSTM1 gene deletion and missense mutation (Pro187Ser) of the NQO1 gene showed no significant association with alcohol withdrawal symptoms.
|
12960511 |
2003 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for breast cancer of double heterozygotes (P187S/R72P) of the NQO1 and TP53 genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.
|
15138483 |
2004 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for breast cancer of double heterozygotes (P187S/R72P) of the NQO1 and TP53 genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.
|
15138483 |
2004 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |
|
Infant Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Previous studies in Caucasian populations have provided evidence that a loss of function allele at nt 609 (C609T, Pro187Ser) is associated with increased risk of infant acute lymphoblastic leukemia (ALL) with MLL-AF4 fusion genes.
|
16266898 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.040 |
GeneticVariation
|
BEFREE |
Results from our meta-analyses suggest that the variant NQO1 Pro187Ser genotype may affect individual susceptibility to lung, bladder, and colorectal cancer.
|
16702380 |
2006 |
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Results from our meta-analyses suggest that the variant NQO1 Pro187Ser genotype may affect individual susceptibility to lung, bladder, and colorectal cancer.
|
16702380 |
2006 |
|
Drug-induced tardive dyskinesia
|
|
0.030 |
GeneticVariation
|
BEFREE |
(2004) reported a significant association between the Pro187Ser polymorphism in the NQO1 gene and TD.
|
16775388 |
2006 |
|
Tardive Dyskinesia
|
|
0.030 |
GeneticVariation
|
BEFREE |
(2004) reported a significant association between the Pro187Ser polymorphism in the NQO1 gene and TD.
|
16775388 |
2006 |
|
Adenocarcinoma of lung (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
In stratified analyses, the NQO1 Pro187Ser variant genotypes were associated with slightly increased lung cancer risk in white ever smokers but not in white never smokers and were mainly associated with a reduced risk of lung adenocarcinoma but not squamous cell carcinoma in Asians.
|
16702380 |
2006 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
In stratified analyses, the NQO1 Pro187Ser variant genotypes were associated with slightly increased lung cancer risk in white ever smokers but not in white never smokers and were mainly associated with a reduced risk of lung adenocarcinoma but not squamous cell carcinoma in Asians.
|
16702380 |
2006 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
In stratified analyses, the NQO1 Pro187Ser variant genotypes were associated with slightly increased lung cancer risk in white ever smokers but not in white never smokers and were mainly associated with a reduced risk of lung adenocarcinoma but not squamous cell carcinoma in Asians.
|
16702380 |
2006 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
In stratified analyses, the NQO1 Pro187Ser variant genotypes were associated with slightly increased lung cancer risk in white ever smokers but not in white never smokers and were mainly associated with a reduced risk of lung adenocarcinoma but not squamous cell carcinoma in Asians.
|
16702380 |
2006 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In stratified analyses, the NQO1 Pro187Ser variant genotypes were associated with slightly increased lung cancer risk in white ever smokers but not in white never smokers and were mainly associated with a reduced risk of lung adenocarcinoma but not squamous cell carcinoma in Asians.
|
16702380 |
2006 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
|
18511948 |
2008 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
|
18511948 |
2008 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Additive effect between quinine oxidoreductase gene (NQO1: Pro187Ser) and manganese superoxide dismutase gene (MnSOD: Ala-9Val) polymorphisms on tardive dyskinesia in patients with schizophrenia.
|
18977034 |
2008 |