Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Interestingly, a common polymorphic form of human NQO1, p.P187S, is associated with an increased risk of several forms of cancer.
|
30518535 |
2019 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Interestingly, a common polymorphic form of human NQO1, p.P187S, is associated with an increased risk of several forms of cancer.
|
30518535 |
2019 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Here, we use biochemical, biophysical, cell and computational biology tools to study two loss-of-function and cancer-associated polymorphisms (p.R139W and p.P187S) in human NAD(P)H quinone oxidoreductase 1 (NQO1), a FAD-dependent enzyme which activates cancer pro-drugs and stabilizes several oncosuppressors.
|
26838129 |
2016 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that Ser allele of NQO1 Pro187Ser significantly contributed to the increased risks of colorectal adenoma and cancer in Caucasians.
|
22306249 |
2012 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Here, we use biochemical, biophysical, cell and computational biology tools to study two loss-of-function and cancer-associated polymorphisms (p.R139W and p.P187S) in human NAD(P)H quinone oxidoreductase 1 (NQO1), a FAD-dependent enzyme which activates cancer pro-drugs and stabilizes several oncosuppressors.
|
26838129 |
2016 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.
|
23860519 |
2013 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
The gene coding for NQO1 has a single nucleotide polymorphism (C-->T) at nucleotide position 609 (proline to serine substitution at position 187 in amino acid sequence (P187S)) (rs1800566) of the NQO1 cDNA which results in very low enzimatic activity, so it would be expected that individuals with the homologous NQO1 C609T polymorphism would have a susceptibility developing cancer.
|
21133623 |
2010 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
In this work, binding of anions to the FAD binding pocket of human NAD(P)H:quinone oxidoreductase 1 (NQO1), a flavoprotein associated with cancer due to a common polymorphism causing a P187S amino acid substitution, was investigated.
|
30615965 |
2019 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
The gene coding for NQO1 has a single nucleotide polymorphism (C-->T) at nucleotide position 609 (proline to serine substitution at position 187 in amino acid sequence (P187S)) (rs1800566) of the NQO1 cDNA which results in very low enzimatic activity, so it would be expected that individuals with the homologous NQO1 C609T polymorphism would have a susceptibility developing cancer.
|
21133623 |
2010 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Structural protein:protein interaction studies reveal that the cancer-associated polymorphism does not abolish the interaction with p73α, indicating that oncosuppressor destabilization largely mirrors the low intracellular stability of p.P187S.
|
28291250 |
2017 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
In this work, binding of anions to the FAD binding pocket of human NAD(P)H:quinone oxidoreductase 1 (NQO1), a flavoprotein associated with cancer due to a common polymorphism causing a P187S amino acid substitution, was investigated.
|
30615965 |
2019 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Additionally, the cancer-associated P187S polymorphism causes inactivation and destabilization of the enzyme.
|
30243998 |
2019 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that Ser allele of NQO1 Pro187Ser significantly contributed to the increased risks of colorectal adenoma and cancer in Caucasians.
|
22306249 |
2012 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Additionally, the cancer-associated P187S polymorphism causes inactivation and destabilization of the enzyme.
|
30243998 |
2019 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Structural protein:protein interaction studies reveal that the cancer-associated polymorphism does not abolish the interaction with p73α, indicating that oncosuppressor destabilization largely mirrors the low intracellular stability of p.P187S.
|
28291250 |
2017 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.
|
23860519 |
2013 |
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for breast cancer of double heterozygotes (P187S/R72P) of the NQO1 and TP53 genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.
|
15138483 |
2004 |
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results of the study suggest that NQO1 exon 6 proline187serine (C609T) and CYP1A2 exon 2 phenylalanine21leucine (C63G) polymorphisms do not play a significant role in breast cancer susceptibility in North Indian women.
|
21329464 |
2011 |
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the stratified analysis by ethnicity, we found that the Pro187Ser polymorphism was associated with increased breast cancer risk in Caucasians in the additive genetic model and dominant genetic model (P = 0.03, OR = 1.13, 95% CI = 1.01-1.26; P = 0.03, OR = 1.15, 95% CI = 1.01-1.30, respectively), whereas no significant in Asians (P = 0.44, OR = 0.94, 95% CI = 0.80-1.10) and postmenopausal women (P = 0.99, OR = 1.00, 95% CI = 0.84-1.19).
|
20526805 |
2011 |
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
|
18511948 |
2008 |
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results of the study suggest that NQO1 exon 6 proline187serine (C609T) and CYP1A2 exon 2 phenylalanine21leucine (C63G) polymorphisms do not play a significant role in breast cancer susceptibility in North Indian women.
|
21329464 |
2011 |
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our meta-analysis provides the evidence that the NQO1 Pro187Ser polymorphism contributed to the breast cancer susceptibility among Caucasians.
|
24884893 |
2014 |
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
|
18511948 |
2008 |