|
Pancreatitis
|
|
0.810 |
GeneticVariation
|
BEFREE |
Effects of PRSS1-PRSS2 rs10273639, CLDN2 rs7057398 and MORC4 rs12688220 polymorphisms on individual susceptibility to pancreatitis: A meta-analysis.
|
31163246 |
2020 |
|
Pancreatitis
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
|
23143602 |
2012 |
|
Pancreatitis
|
|
0.810 |
GeneticVariation
|
GWASDB |
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
|
23143602 |
2012 |
|
Pancreatitis, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Moreover, rs12688220 and rs10273639 polymorphisms could be used to identify individuals at an elevated susceptibility chronic pancreatitis in Asians.
|
31163246 |
2020 |
|
Pancreatitis, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Taken together, the results from our study do not support variants rs11988997, rs379742, rs10273639, rs2995271 and rs12688220 as strong predictors of PDAC risk, but further support the role of these SNPs in CP susceptibility.
|
28913878 |
2018 |
|
Pancreatitis, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study confirmed a significant association of 2 variants in CLDN2 gene (rs4409525-OR 1.71, P = 1.38 x 10-09; rs12008279-OR 1.56, P = 1.53 x 10-04) and 2 variants in MORC4 gene (rs12688220-OR 1.72, P = 9.20 x 10-09; rs6622126-OR 1.75, P = 4.04x10-05) in Indian patients with CP.
|
26820620 |
2016 |
|
Pancreatitis, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphisms rs10273639 at the PRSS1-PRSS2 locus and rs7057398 and rs12688220 at the CLDN2-MORC4 locus are associated with CP and strongly associate with ACP, but only rs7057398 with NACP in female patients.
|
25253127 |
2015 |
|
Acute pancreatitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings suggested that rs7057398, rs12688220 and rs10273639 polymorphisms could be used to identify individuals at an elevated susceptibility to acute pancreatitis in Caucasians.
|
31163246 |
2020 |
|
Acute pancreatitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Meta-analyses of all AP patients depicted significant (p-value < 0.05) associations for rs10273639 (odds ratio (OR) 0.88, 95% confidence interval (CI) 0.81-0.97, p-value 0.01), rs7057398 (OR 1.27, 95% CI 1.07-1.5, p-value 0.005), and rs12688220 (OR 1.32, 95% CI 1.12-1.56, p-value 0.001).
|
29884332 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
Taken together, the results from our study do not support variants rs11988997, rs379742, rs10273639, rs2995271 and rs12688220 as strong predictors of PDAC risk, but further support the role of these SNPs in CP susceptibility.
|
28913878 |
2018 |
|
Pancreatitis, Alcoholic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a much broader approach employing genome wide search strategies the NAPS study found that polymorphisms in the Trypsin locus (PRSS1 rs10273639), and the Claudin 2 locus (CLDN2-RIPPLY1-MORC4 locus rs7057398 and rs12688220) confer an increased risk of developing alcohol-induced pancreatitis.
|
26149858 |
2015 |