|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our purpose was to determine the genotype frequencies of six different SNPs in genes that encode proteins involved in AMD-related molecular changes (SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919) for evaluation of haplotype risk in patients with AMD.
|
30399423 |
2019 |
|
Pituitary Adenoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The haplotype containing alleles C-A in rs12778366-rs3740051 was found to be associated with increased odds of PA development as well.
|
31747893 |
2019 |
|
Pituitary Adenoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SIRT1 rs12778366 polymorphism analysis in the overall group revealed differences in the genotype distribution between patients with PA and control group subjects.
|
28521414 |
2017 |
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association between targeted SNPs and AMD was then analyzed by codominant, dominant, recessive, and allelic models.The genotyping data of rs12778366, rs3740051, and rs4746720 revealed significant deviations from Hardy-Weinberg equilibrium tests in the AMD group but not in the control group.We detected significantly differences of rs12778366 allele distribution between 2 groups in recessive and codominant model (P < 0.05).
|
26656366 |
2015 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results showed that rs12778366 in the promoter region of SIRT1 and rs2015 in the 3'untranslated region (3'UTR) of the SIRT2 were significantly associated with the risk of PD.
|
31214610 |
2019 |
|
Laryngeal Squamous Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with laryngeal squamous cell carcinoma (LSCC).
|
31781300 |
2019 |
|
Diabetic Foot
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 2 studied polymorphisms had no effects on its gene expression (P > .05 for all).SIRT1 rs12778366 polymorphism C allele might act as a protective factor for DF onset.
|
29995800 |
2018 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Sex- and subsite-specific Cox hazard ratios (HRs) showed that the rs12778366 CC versus TT genotype decreased CRC and colon cancer risks in women (HR<sub>CRC</sub> = 0.53, 95% confidence interval: 0.30-0.94) but not men.
|
30410074 |
2018 |
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Sex- and subsite-specific Cox hazard ratios (HRs) showed that the rs12778366 CC versus TT genotype decreased CRC and colon cancer risks in women (HR<sub>CRC</sub> = 0.53, 95% confidence interval: 0.30-0.94) but not men.
|
30410074 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results were adjusted using logistic regression analysis.C allele of rs12778366 polymorphism was significantly correlated with reduced DF susceptibility which deriving from healthy controls (adjusted OR = 0.364, 95% CI = 0.158-0.835) so was patients with T2DM (P = .047, OR = 0.591, 95%CI = 0.349-0.998), but the results became nonsignificant adjusted by clinical features (adjusted OR = 0.654, 95% CI = 0.391-1.094).
|
29995800 |
2018 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Sex- and subsite-specific Cox hazard ratios (HRs) showed that the rs12778366 CC versus TT genotype decreased CRC and colon cancer risks in women (HR<sub>CRC</sub> = 0.53, 95% confidence interval: 0.30-0.94) but not men.
|
30410074 |
2018 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that rs3758391 and rs12778366 polymorphisms of SIRT1 gene are associated with breast cancer risk and prognosis in the Egyptian population.
|
26999517 |
2016 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that rs3758391 and rs12778366 polymorphisms of SIRT1 gene are associated with breast cancer risk and prognosis in the Egyptian population.
|
26999517 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
SIRT1 promoter rs12778366 and rs3758391 may account for differential expression of this molecule and the role of these variants was investigated in SLE susceptibility and morbidity.
|
24570024 |
2014 |
|
Shared Paranoid Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database.
|
21882241 |
2011 |